Increased p50/p50 NF-κB activation in human papillomavirus type 6-or type 11-induced laryngeal papilloma tissue

被引：38

作者：

Vancurova, I

Wu, R

Miskolci, V

Sun, SS

机构：

[1] Long Isl Jewish Med Ctr, Dept Otolaryngol, New Hyde Pk, NY 11040 USA

[2] Long Isl Jewish Med Ctr, Dept Pediat, New Hyde Pk, NY 11040 USA

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 03期

关键词：

D O I：

10.1128/JVI.76.3.1533-1536.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have observed elevated NF-KB DNA-binding activity in nuclear extracts from human papillomavirus type 6- and 11-infected laryngeal papilloma tissues. The predominant DNA-binding species is the p50/p50 homodimer. The elevated NF-KB activity could be correlated with a reduced level of cytoplasmic IKBbeta and could be associated with the overexpression of p21(CIP1/WAF1) in papilloma cells. Increased NF-KB activity and cytoplasmic accumulation of p21(CIP1/WAF1) might counteract death-promoting effects elicited by overexpressed PTEN and reduced activation of Akt and STAT3 previously noted in these tissues.

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页码：1533 / 1536

页数：4

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