Transition metal catalysed reactions of alcohols using borrowing hydrogen methodology

被引：602

作者：

Nixon, Tracy D. ^{[1
]}

Whittlesey, Michael K. ^{[1
]}

Williams, Jonathan M. J. ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

来源：

DALTON TRANSACTIONS | 2009年 / 05期

基金：

英国工程与自然科学研究理事会;

关键词：

N-HETEROCYCLIC CARBENE; C BOND FORMATION; RUTHENIUM-GRAFTED HYDROTALCITE; DIRECT ALPHA-ALKYLATION; ASTERISK-IR COMPLEX; SECONDARY ALCOHOLS; PRIMARY AMINES; 2-AMINOBENZYL ALCOHOL; ELECTRONIC ACTIVATION; SELECTIVE SYNTHESIS;

D O I：

10.1039/b813383b

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The reactivity of alcohols can be enhanced by the temporary removal of hydrogen using a transition metal catalyst to generate an intermediate aldehyde or ketone. The so-formed carbonyl compound has a greater reactivity towards nucleophilic addition accommodating the in situ formation of imines or alkenes. The return of hydrogen from the catalyst leads to the formation of new C-N and C-C bonds, often with water as the only reaction by-product.

引用

页码：753 / 762

页数：10

共 98 条

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