Cyano-phosphorylation of aldehydes catalyzed by a nucleophilic N-heterocyclic carbene

被引：32

作者：

Fukuda, Y ^{[1
]}

Maeda, Y ^{[1
]}

Kondo, K ^{[1
]}

Aoyama, T ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 03期

关键词：

cyano-phosphorylation; N-heterocyclic carbene; imidazolium salt; nucleophilic catalyst;

D O I：

10.1248/cpb.54.397

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The first method for cyano-phosphorylation of aldehydes with diethyl cyanophosphonate in the presence of N-heterocyclic carbene prepared from 1,3-bis(2,4,6-trimethylphenvl)imidazolium chloride and KOt-Bu, as a nucleophilic catalyst, is described.

引用

页码：397 / 398

页数：2

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