Mimics of the sialyl Lewis X tetrasaccharide. Replacement of the N-acetylglucosamine sugar with simple C-2-symmetric 1,2-diols

被引：19

作者：

Prodger, JC

Bamford, MJ

Bird, MI

Gore, PM

Holmes, DS

Priest, R

Saez, V

机构：

[1] GLAXO RES & DEV LTD,GLAXO WELLCOME MED RES CTR,DEPT MED CHEM,STEVENAGE SG1 2NY,HERTS,ENGLAND

[2] GLAXO RES & DEV LTD,GLAXO WELLCOME MED RES CTR,DEPT MOLEC SCI,STEVENAGE SG1 2NY,HERTS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1996年 / 4卷 / 06期

关键词：

D O I：

10.1016/0968-0896(96)00055-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analogues of sialyl Lewis X have been synthesized that feature replacement of the N-acetylglucosamine residue with C-2-symmetric diols. The diols used contain different levels of torsional constraint and various functional groups. The cyclohexyl derived compound 27 was equipotent to sLex in vitro (IC50 0.5 mM). Copyright (C) 1996 Elsevier Science Ltd

引用

页码：793 / 801

页数：9

共 31 条

[1] THE SYNTHESIS OF NOVEL MIMICS OF THE SIALYL-LEWIS-X DETERMINANT [J].