Regulatory T cells and treatment of cancer

被引:219
作者
Curiel, Tyler J. [1 ]
机构
[1] Univ Texas Hlth Sci Ctr San Antonio, Canc Therapy & Res Ctr, San Antonio, TX 78229 USA
关键词
D O I
10.1016/j.coi.2008.04.008
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
CD4+CD25+FOXP3+ regulatory T cells (Tregs) are elevated in cancers and can thwart protective antitumor immunity. Recent human cancer trials suggest that depleting Tregs can be clinically beneficial. Additional types of deleterious regulatory cells are also increased in cancer. Tregs also play unanticipated roles in cancer therapy in that some drugs unexpectedly increase (e.g. cancer vaccines or IL-2 treatment) or decrease (e.g. antineoangiogenesis agents or receptor tyrosine kinase inhibitors) their numbers or function. Managing deleterious effects of regulatory cells represents a novel and potentially effective way to give immunotherapy for cancer. New insights into molecular mechanisms governing trafficking, differentiation, and function of these cells suggest novel approaches to manipulating them as treatment strategies.
引用
收藏
页码:241 / 246
页数:6
相关论文
共 68 条
[31]   GATA3-driven Th2 responses inhibit TGF-β1-induced FOXP3 expression and the formation of regulatory T cells [J].
Mantel, Pierre-Yves ;
Kuipers, Harmjan ;
Boyman, Onur ;
Rhyner, Claudio ;
Ouaked, Nadia ;
Ruckert, Beateru ;
Karagiannidis, Christian ;
Lambrecht, Bart N. ;
Hendriks, Rudolf W. ;
Crameri, Reto ;
Akdis, Cezmi A. ;
Blaser, Kurt ;
Schmidt-Weber, Carsten B. .
PLOS BIOLOGY, 2007, 5 (12) :2847-2861
[32]   Local and systemic induction of CD4+CD25+ regulatory T-cell population by non-Hodgkin lymphoma [J].
Mittal, Sajjan ;
Marshall, Neil A. ;
Duncan, Linda ;
Culligan, Dominic J. ;
Barker, Robert N. ;
Vickers, Mark A. .
BLOOD, 2008, 111 (11) :5359-5370
[33]   Localisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer [J].
Mizukami, Y. ;
Kono, K. ;
Kawaguchi, Y. ;
Akaike, H. ;
Kamimura, K. ;
Sugai, H. ;
Fujii, H. .
BRITISH JOURNAL OF CANCER, 2008, 98 (01) :148-153
[34]   Intradermal CpG-B activates both plasmacytoid and myeloid dendritic cells in the sentinel lymph node of melanoma patients [J].
Molenkamp, Barbara G. ;
van Leeuwen, Paul A. M. ;
Meijer, Sybren ;
Sluijter, Berbel J. R. ;
Wijnands, Pepijn G. J. T. B. ;
Baars, Arnold ;
van den Eertwegh, Alfons J. M. ;
Scheper, Rik J. ;
de Grujil, Tanja D. .
CLINICAL CANCER RESEARCH, 2007, 13 (10) :2961-2969
[35]   CD4+CD25hi regulatory T-cell frequency correlates with persistence of human papillomavirus type 16 and T helper cell responses in patients with cervical intraepithelial neoplasia [J].
Molling, Johan W. ;
de Gruijl, Tanja D. ;
Glim, Judith ;
Moreno, Maria ;
Rozendaal, Lawrence ;
Meijer, Chris J. L. M. ;
van den Eertwegh, Alfons J. M. ;
Scheper, Rik J. ;
von Blomberg, Mary E. ;
Bontkes, Hetty J. .
INTERNATIONAL JOURNAL OF CANCER, 2007, 121 (08) :1749-1755
[36]   Vaccination against the forkhead family transcription factor Foxp3 enhances tumor immunity [J].
Nair, Smita ;
Boczkowski, David ;
Fassnacht, Martin ;
Pisetsky, David ;
Gilboa, Eli .
CANCER RESEARCH, 2007, 67 (01) :371-380
[37]   Listeriolysin O expressed in a bacterial vaccine suppresses CD4+ CD25high regulatory T cell function in vivo [J].
Nitcheu-Tefit, Josianne ;
Dai, Ming-Shen ;
Critchley-Thorne, Rebecca J. ;
Ramirez-Jimenez, Francisco ;
Xu, Man ;
Conchon, Sophie ;
Ferry, Nicolas ;
Stauss, Hans J. ;
Vassaux, Georges .
JOURNAL OF IMMUNOLOGY, 2007, 179 (03) :1532-1541
[38]   A pilot study of CTLA-4 blockade after cancer vaccine failure in patients with advanced malignancy [J].
O'Mahony, Deirdre ;
Morris, John C. ;
Quinn, Cate ;
Gao, Wendy ;
Wilson, Wyndham H. ;
Gause, Barry ;
Pittaluga, Stefania ;
Neelapu, Sattva ;
Brown, Margaret ;
Fleisher, Thomas A. ;
Gulley, James L. ;
Schlom, Jeffrey ;
Nussenblatt, Robert ;
Albert, Paul ;
Davis, Thomas A. ;
Lowy, Israel ;
Petrus, Mike ;
Waldmann, Thomas A. ;
Janik, John E. .
CLINICAL CANCER RESEARCH, 2007, 13 (03) :958-964
[39]   Calreticulin exposure dictates the immunogenicity of cancer cell death [J].
Obeid, Michel ;
Tesniere, Antoine ;
Ghiringhelli, Francois ;
Fimia, Gian Maria ;
Apetoh, Lionel ;
Perfettini, Jean-Luc ;
Castedo, Maria ;
Mignot, Gregoire ;
Panaretakis, Theoharis ;
Casares, Noelia ;
Metivier, Didier ;
Larochette, Nathanael ;
van Endert, Peter ;
Ciccosanti, Fabiola ;
Piacentini, Mauro ;
Zitvogel, Laurence ;
Kroemer, Guido .
NATURE MEDICINE, 2007, 13 (01) :54-61
[40]   Role of STAT3 in CD4+CD25+FOXP3+ regulatory lymphocyte generation:: Implications in graft-versus-host disease and antitumor immunity [J].
Pallandre, Jean-Rene ;
Brillard, Emilie ;
Crehange, Gilles ;
Radlovic, Amandine ;
Remy-Martin, Jean-Paul ;
Saas, Philippe ;
Rohrlich, Pierre-Simon ;
Pivot, Xavier ;
Ling, Xiang ;
Tiberghien, Pierre ;
Borg, Christophe .
JOURNAL OF IMMUNOLOGY, 2007, 179 (11) :7593-7604