Preparation and biological evaluation of 6/7-trifluoromethyl(nitro)-, 6,7-difluoro-3-alkyl (aryl)-substituted-quinoxalin-2-ones. Part 3

被引：71

作者：

Sanna, P

Carta, A

Loriga, M

Zanetti, S

Sechi, L

机构：

[1] Dipartimento Farmaco Chim Tossicol, I-07100 Sassari, Italy

[2] Dipartimento Sci Biomed, I-07100 Sassari, Italy

来源：

FARMACO | 1999年 / 54卷 / 03期

关键词：

2-quinoxalinones; antibacterial; antifungal; antimycobacterial activities; anticancer activities;

D O I：

10.1016/S0014-827X(99)00011-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A new series of quinoxalinones 6/7-trifluoromethyl or nitro- and 6,7-difluoro substituted bearing various side-chains (alkyl, halogenoalkyl, benzyl and phenyl groups) at C-3 of the ring system was synthesized and submitted to preliminary in vitro evaluation for antibacterial, antifungal, antimycobacterial, anticancer and anti-HIV activities. Results of these screenings showed that compounds 23-28 exhibited a good inhibition activity against various strains of Candida. Compound 24 showed also an interesting in vitro anticancer activity. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：169 / 177

页数：9

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