Fibulin 1 is downregulated through promoter hypermethylation in gastric cancer

被引：70

作者：

Cheng, Y. Y. ^{[1
]}

Jin, H. ^{[1
]}

Liu, X. ^{[1
]}

Siu, J. M. T. ^{[1
]}

Wong, Y. P. ^{[1
]}

Ng, E. K. O. ^{[1
]}

Yu, J. ^{[1
]}

Leung, W-K ^{[1
]}

Sung, J. J. Y. ^{[1
]}

Chan, F. K. L. ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Fac Med, Dept Med & Therapeut,Inst Digest Dis, Shatin, Hong Kong, Peoples R China

来源：

BRITISH JOURNAL OF CANCER | 2008年 / 99卷 / 12期

关键词：

FBLN1; methylation; tumour suppressor gene; gastric cancer;

D O I：

10.1038/sj.bjc.6604760

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Tumour suppressor genes (TSGs) were frequently inactivated through promoter hypermethylation in gastric carcinoma as well as pre-malignant gastric lesions, suggesting that promoter hypermethylation can be used as a marker to define novel TSGs and also biomarkers for early detection of gastric cancer. In an effort to search for such genes aberrantly methylated in gastric cancer development, fibulin 1 (FBLN1) was found as a candidate TSG epigenetically downregulated in gastric cancer. FBLN1 expression was downregulated in all of gastric cancer cell lines used (100%, 7 out of 7) and the primary gastric carcinoma tissues (84%, 86 out of 102) and significantly restored after pharmacological demethylation. Hypermethylation of the FBLN1 promoter was frequently (71%, 5 out of 7) detected in gastric cancer cell lines and primary gastric carcinoma tissues. Ectopic expression of FBLN1 led to the growth inhibition of gastric cancer cells through the induction of apoptosis. In summary, FBLN1 was identified as a novel candidate TSG epigenetically downregulated in gastric cancer.

引用

页码：2083 / 2087

页数：5

共 26 条

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