Differential responsiveness of inbred strains of rats to antidepressants in the forced swimming test: Are Wistar Kyoto rats an animal model of subsensitivity to antidepressants?

被引:81
作者
Lahmame, A [1 ]
Armario, A [1 ]
机构
[1] UNIV AUTONOMA BARCELONA,FAC CIENCIES,UNITAT FISIOL ANIM,DEPT BIOL CELULAR & FISIOL,E-08193 BELLATERRA,SPAIN
关键词
holeboard; forced swimming test; brown Norway rats; Fisher; 344; rats; Lewis rats; spontaneously hypertensive rats; Wistar Kyoto rats; Desipramine; 8-OH-DPAT;
D O I
10.1007/BF02246177
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In three experiments we have studied the effects of acute administration of various doses (5, 10, 15 and 25 mg/kg) of desipramine (DMI) and two doses (0.5 and 2 mg/kg) of 8-hydroxy-2-(di-M-propylamino)tetralin (8-OH-DPAT), a selective 5HT(1A) receptor agonist, on behaviour of five inbred strains of rats in the holeboard and the forced swimming test (FST). The strains were Brown-Norway (BN), Fischer 344 (FIS), Lewis (LEW), Spontaneously Hypertensive Rats (SHR) and Wistar-Kyoto (WKY). In drug-free conditions, the strains showed striking differences in their activity in the holeboard and in the FST, the WKY rats being the most passive in both tests. The dose of 15 mg/kg DMI caused a profound inhibitory effect on locomotor/exploration activity in all strains. In the FST, this dose of DMI increased struggling and reduced immobility in BN, FIS and LEW rats, but did not exert any effect in SHR and WKY rats. The lack of marked strain-dependent differences in the sensitivity to the inhibitory effects of DMI on locomotor activity or exploration rule out a major role of changes in the metabolism of drug among strains as an explanation for differential response to DMI in the FST. In further experiments three strains were used: BN (responsive), WKY (non-responsive) and the outbred Sprague Dawley (SD) rats. In the FST, both DMI and 8-OH-DPAT, at all doses, decreased immobility and increased struggling in BN and SD rats. However, WKY rats responded only to a very high dose of DMI (25 mg/kg). Hence, WKY rats are not only passive in the FST, but are also subsensitive to acute antidepressant administration. The present data indicate that the levels of activity of animals in the FST in drug-free conditions are not predictive of their response to antidepressants, and that inbred strains might be useful for studying the biological basis of subsensitivity to antidepressants and depressive-like behaviour.
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页码:191 / 198
页数:8
相关论文
共 40 条
[1]   FORCED SWIMMING TEST IN RATS - EFFECT OF DESIPRAMINE ADMINISTRATION AND THE PERIOD OF EXPOSURE TO THE TEST ON STRUGGLING BEHAVIOR, SWIMMING, IMMOBILITY AND DEFECATION RATE [J].
ARMARIO, A ;
GAVALDA, A ;
MARTI, O .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 158 (03) :207-212
[2]   INFLUENCE OF VARIOUS ACUTE STRESSORS ON THE ACTIVITY OF ADULT MALE-RATS IN A HOLEBOARD AND IN THE FORCED SWIM TEST [J].
ARMARIO, A ;
GIL, M ;
MARTI, J ;
POL, O ;
BALASCH, J .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1991, 39 (02) :373-377
[3]  
ARMARIO A, 1995, IN PRESS PSYCHONEURO
[4]   DOES THE BEHAVIORAL DESPAIR TEST MEASURE DESPAIR [J].
BORSINI, F ;
VOLTERRA, G ;
MELI, A .
PHYSIOLOGY & BEHAVIOR, 1986, 38 (03) :385-386
[5]   8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN, A SELECTIVE SEROTONIN1A RECEPTOR AGONIST, REDUCES THE IMMOBILITY OF RATS IN THE FORCED SWIMMING TEST BY ACTING ON THE NUCLEUS RAPHE DORSALIS [J].
CERVO, L ;
GRIGNASCHI, G ;
SAMANIN, R .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 158 (1-2) :53-59
[6]   DIFFERENT EFFECTS OF INTRACEREBRAL AND SYSTEMIC ADMINISTRATION OF BUSPIRONE IN THE FORCED SWIMMING TEST - INVOLVEMENT OF A METABOLITE [J].
CERVO, L ;
GRIGNASCHI, G ;
SAMANIN, R .
LIFE SCIENCES, 1988, 43 (25) :2095-2102
[7]   EFFECT OF CHRONIC TREATMENT WITH 8-OH-DPAT IN THE FORCED SWIMMING TEST REQUIRES THE INTEGRITY OF PRESYNAPTIC SEROTONERGIC MECHANISMS [J].
CERVO, L ;
SAMANIN, R .
PSYCHOPHARMACOLOGY, 1991, 103 (04) :524-528
[8]   INVOLVEMENT OF 5-HT1A RECEPTORS IN THE ANTIDEPRESSANT-LIKE ACTIVITY OF GEPIRONE IN THE FORCED SWIMMING TEST IN RATS [J].
CHOJNACKAWOJCIK, E ;
TATARCZYNSKA, E ;
GOLEMBIOWSKA, K ;
PRZEGALINSKI, E .
NEUROPHARMACOLOGY, 1991, 30 (07) :711-717
[9]   VALIDITY OF HEAD-DIPPING AS A MEASURE OF EXPLORATION IN A MODIFIED HOLE-BOARD [J].
FILE, SE ;
WARDILL, AG .
PSYCHOPHARMACOLOGIA, 1975, 44 (01) :53-59
[10]   INTERACTION BETWEEN CHRONIC STRESS AND CLOMIPRAMINE TREATMENT IN RATS - EFFECTS ON EXPLORATORY ACTIVITY, BEHAVIORAL DESPAIR, AND PITUITARY-ADRENAL-FUNCTION [J].
GARCIAMARQUEZ, C ;
ARMARIO, A .
PSYCHOPHARMACOLOGY, 1987, 93 (01) :77-81