Current Approaches to the Evaluation and Management of the Fetus and Neonate with Immune Thrombocytopenia

被引：44

作者：

Bussel, James B. ^{[1
]}

Sola-Visner, Martha ^{[2
,3
]}

机构：

[1] New York Presbyterian Hosp, Weill Cornell Med Coll, Div Pediat Hematol Oncol, New York, NY 10065 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Childrens Hosp Boston, Boston, MA USA

来源：

SEMINARS IN PERINATOLOGY | 2009年 / 33卷 / 01期

关键词：

newborn; fetus; thrombocytopenia; platelet transfusions; IVIG; FETAL ALLOIMMUNE THROMBOCYTOPENIA; INTRACRANIAL HEMORRHAGE; PLATELET TRANSFUSION; ANTENATAL MANAGEMENT; MAIPA ASSAY; RISK; ANTIGEN; CORDOCENTESIS; ANTIBODY; THERAPY;

D O I：

10.1053/j.semperi.2008.10.003

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Fetal and neonatal alloimmune thrombocytopenia is not a well-known disease, except among specialists in maternal-fetal medicine, neonatologists, and certain pediatricians (ie, hematologists). However, this is by far the most common cause of early severe thrombocytopenia in neonates and of intracranial hemorrhage in term neonates. In addition, if a newborn is affected with alloimmune thrombocytopenia, the next child in the family will likely be more severely affected. Thus, the accurate diagnosis and appropriate management of this disorder are of extreme importance in perinatal medicine and will constitute the focus of this review.

引用

页码：35 / 42

页数：8

共 39 条

[21] FETAL THROMBOCYTOPENIA - A RETROSPECTIVE SURVEY OF 5,194 FETAL BLOOD SAMPLINGS [J].

HOHLFELD, P ;

FORESTIER, F ;

KAPLAN, C ;

TISSOT, JD ;

DAFFOS, F .

BLOOD, 1994, 84 (06) :1851-1856

[22] HPA-5B (BRA) NEONATAL ALLOIMMUNE THROMBOCYTOPENIA - CLINICAL AND IMMUNOLOGICAL ANALYSIS OF 39 CASES [J].

KAPLAN, C ;

MORELKOPP, MC ;

KROLL, H ;

KIEFEL, V ;

SCHLEGEL, N ;

CHESNEL, N ;

MUELLERECKHARDT, C .

BRITISH JOURNAL OF HAEMATOLOGY, 1991, 78 (03) :425-429

[23] Antigen-positive platelet transfusion in neonatal alloimmune thrombocytopenia (NAIT) [J].

Kiefel, V ;

Bassler, D ;

Kroll, H ;

Paes, B ;

Giers, G ;

Ditomasso, J ;

Alber, H ;

Berns, M ;

Wiebe, B ;

Quenzel, EM ;

Hoch, J ;

Greinacher, A .

BLOOD, 2006, 107 (09) :3761-3763

[24] A prospective study of maternal anti-HPA 1a antibody level as a potential predictor of alloimmune thrombocytopenia in the newborn [J].

Killie, Mette Kjaer ;

Husebekk, Anne ;

Kjeldsen-Kragh, Jens ;

Skogen, Bjorn .

HAEMATOLOGICA, 2008, 93 (06) :870-877

[25] A screening and intervention program aimed to reduce mortality and serious morbidity associated with severe neonatal alloimmune thrombocytopenia [J].

Kjeldsen-Kragh, Jens ;

Killie, Mette Kjaer ;

Tomter, Geir ;

Golebiowska, Elzbieta ;

Randen, Ingrid ;

Hauge, Reidun ;

Aune, Berit ;

Oian, Pal ;

Dahl, Lauritz B. ;

Pirhonen, Jouko ;

Lindeman, Rolf ;

Husby, Henrik ;

Haugen, Guttorm ;

Gronn, Morten ;

Skogen, Bjorn ;

Husebekk, Anne .

BLOOD, 2007, 110 (03) :833-839

[26] The gene for May-Hegglin anomaly localizes to a <1-mb region on chromosome 22q12.3-13.1 [J].

Martignetti, JA ;

Heath, KE ;

Harris, J ;

Bizzaro, N ;

Savoia, A ;

Balduini, CL ;

Desnick, RJ .

AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 66 (04) :1449-1454

[27] THROMBOCYTOPENIA IN THE HIGH-RISK INFANT [J].

MEHTA, P ;

VASA, R ;

NEUMANN, L ;

KARPATKIN, M .

JOURNAL OF PEDIATRICS, 1980, 97 (05) :791-794

[28] Practice parameter: Neuroimaging of the neonate - Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society [J].

Ment, LR ;

Bada, HS ;

Barnes, P ;

Grant, PE ;

Hirtz, D ;

Papile, LA ;

Pinto-Martin, J ;

Rivkin, M ;

Slovis, TL .

NEUROLOGY, 2002, 58 (12) :1726-1738

[29] HIGH-DOSE IGG TREATMENT FOR NEONATAL ALLOIMMUNE THROMBOCYTOPENIA [J].

MUELLERECKHARDT, C ;

KIEFEL, V ;

GRUBERT, A .

BLUT, 1989, 59 (01) :145-146

[30]

MULLER JY, 1985, PRESSE MED, V1, P363

← 1 2 3 4 →