Oxgen:: Modulator of physiological and pathophysiological processes in the liver

被引：41

作者：

Kietzmann, T ^{[1
]}

Dimova, EY

Flügel, D

Scharf, JG

机构：

[1] Univ Kaiserslautern, Fac Chem, Dept Biochem, D-67663 Kaiserslautern, Germany

[2] Univ Gottingen, Med Klin & Poliklin, Gottingen, Germany

来源：

ZEITSCHRIFT FUR GASTROENTEROLOGIE | 2006年 / 44卷 / 01期

关键词：

metabolic zonation; IGF binding protein-1; HIF; PHD;

D O I：

10.1055/s-2005-858987

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Oxygen has important functions as substrate for biochemical reactions and as modulator of gene expression. In the liver, the physiologically occurring oxygen gradient is a major effector of metabolic zonation. In addition, cross-talks between the O-2 signaling and nutrient signaling chains initiate a dynamic zonation pattern. Under pathological situations, hypoxia appears to be a major determinant for liver diseases and cancer. Thereby transcription factors of the HIF family are activated whereas USF proteins have the potential to counteract HIFs. In addition, feedback mechanisms between hypoxia, HIF and the IGF axes appear to exist. Thus, the knowledge of these mechanisms may help to initiate new therapies in diseases with disturbed O-2 availability.

引用

页码：67 / 76

页数：10

共 151 条

[1]

Andreasen PA, 1997, INT J CANCER, V72, P1, DOI 10.1002/(SICI)1097-0215(19970703)72:1<1::AID-IJC1>3.0.CO

[2]

2-Z

[3] Gene expression of insulin-like growth factor-I, its receptor and binding proteins in retina under hypoxic conditions [J].

Averbukh, E ;

Weiss, O ;

Halpert, M ;

Yanko, R ;

Moshe, R ;

Nephesh, I ;

Flyvbjerg, A ;

Yanko, L ;

Raz, I .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1998, 47 (11) :1331-1336

[4] INSULIN-LIKE GROWTH-FACTORS AND DIABETES [J].

BACH, LA ;

RECHLER, MM .

DIABETES-METABOLISM REVIEWS, 1992, 8 (03) :229-257

[5] Regulation of the Drosophila bHLH-PAS protein Sima by hypoxia:: Functional evidence for homology with mammalian HIF-1α [J].

Bacon, NCM ;

Wappner, P ;

O'Rourke, JF ;

Bartlett, SM ;

Shilo, B ;

Pugh, CW ;

Ratcliffe, PJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 249 (03) :811-816

[6] Chelation of cellular calcium modulates hypoxia-inducible gene expression through activation of hypoxia-inducible factor-1α [J].

Berchner-Pfannschmidt, U ;

Petrat, F ;

Doege, K ;

Trinidad, B ;

Freitag, P ;

Metzen, E ;

de Groot, H ;

Fandrey, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (43) :44976-44986

[7] CIS-REGULATION OF THE L-TYPE PYRUVATE-KINASE GENE PROMOTER BY GLUCOSE, INSULIN AND CYCLIC-AMP [J].

BERGOT, MO ;

DIAZGUERRA, MJM ;

PUZENAT, N ;

RAYMONDJEAN, M ;

KAHN, A .

NUCLEIC ACIDS RESEARCH, 1992, 20 (08) :1871-1878

[8] Plasminogen activator inhibitor 1: Physiological and pathophysiological roles [J].

Binder, BR ;

Christ, G ;

Gruber, F ;

Grubic, N ;

Hufnagl, P ;

Krebs, M ;

Mihaly, J ;

Prager, GW .

NEWS IN PHYSIOLOGICAL SCIENCES, 2002, 17 :56-61

[9]

Blakesley Vicky A., 1996, Cytokine and Growth Factor Reviews, V7, P153, DOI 10.1016/1359-6101(96)00015-9

[10] Levels of hypoxia-inducible factor-1α during breast carcinogenesis [J].

Bos, R ;

Zhong, H ;

Hanrahan, CF ;

Mommers, ECM ;

Semenza, GL ;

Pinedo, HM ;

Abeloff, MD ;

Simons, JW ;

van Diest, PJ ;

van der Wall, E .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2001, 93 (04) :309-314

← 1 2 3 4 5 6 7 8 9 10 →