Evaluation of somnolence in Parkinson's disease: Comparison with age and sex-matched controls

被引:107
作者
Tan, EK
Lum, SY
Fook-Chong, SMC
Teoh, ML
Yih, Y
Tan, L
Tan, A
Wong, MC
机构
[1] Singapore Gen Hosp, Dept Neurol, Parkinsons Dis & Movement Disorder Program, Singapore 169608, Singapore
[2] Singapore Gen Hosp, Dept Clin Res, Singapore 0316, Singapore
[3] Singapore Gen Hosp, Dept Hlth Screening, Singapore 0316, Singapore
[4] Natl Inst Neurosci, Singapore, Singapore
关键词
D O I
10.1212/WNL.58.3.465
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The authors found a significantly higher prevalence of daytime somnolence in 201 patients with PD compared with 214 age- and sex-matched healthy control subjects (Epworth Sleepiness Scale score 5.6 vs 4.6). The prevalence of "sleep attacks" (SA) was about seven times higher in patients with PD than in control subjects (13.9% vs 1.9%; p < 0.0005). Multivariate analysis demonstrated that a higher dose of levodopa and longer duration of disease significantly predicted for SA in patients with PD. Epworth Sleepiness Scale scores of greater than or equal to10 had 71.4% sensitivity and 88.4% specificity for SA.
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页码:465 / 468
页数:4
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