Insulin-like growth factors and prostate cancer

被引：139

作者：

Pollak, M

Beamer, W

Zhang, JC

机构：

[1] McGill Univ, Jewish Gen Hosp, Montreal, PQ H3T 1E2, Canada

[2] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

CANCER AND METASTASIS REVIEWS | 1998年 / 17卷 / 04期

关键词：

IGF-I; prostate; risk; prevention; treatment; proliferation;

D O I：

10.1023/A:1006154108619

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Converging data from epidemiological and biological research implicate insulin-like growth factor (IGF) physiology in the regulation of prostate epithelial cell proliferation and in the pathophysiology of prostate cancer. This review (1) outlines elements of IGF physiology, (2) reviews recent evidence that circulating IGF-I level is related to risk of prostate cancer, (3) provides a hypothesis concerning the biological basis for the relationship between IGF-1 level and risk of prostate cancer, (4) discusses IGF-I physiology in the context of neoplastic progression of prostate cancer, and (5) discusses clinical implications of these lines of research with respect to prevention and treatment.

引用

页码：383 / 390

页数：8

共 43 条

[1] Cancer - Study suggests new way to gauge prostate cancer risk [J].