TGF-β signaling in cancer -: a double-edged sword

被引：572

作者：

Akhurst, RJ ^{[1
]}

Derynck, R

机构：

[1] Univ Calif San Francisco, Mt Zion Canc Res Inst, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Growth & Dev, Cell Biol Program, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Growth & Dev, Program Dev Biol, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Anat, Program Dev Biol, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Dept Growth & Dev, Program Dev Biol, San Francisco, CA 94143 USA

来源：

TRENDS IN CELL BIOLOGY | 2001年 / 11卷 / 11期

关键词：

D O I：

10.1016/S0962-8924(01)02130-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transforming growth factor (TGF) beta1 is a potent growth inhibitor, with tumor-suppressing activity. Cancers are often refractile to this growth inhibition either because of genetic loss of TGF-beta signaling components or, more commonly, because of downstream perturbation of the signaling pathway, such as by Ras activation. Carcinomas often secrete excess TGF-beta1 and respond to it by enhanced invasion and metastasis. Therapeutic approaches should aim to inhibit the TGF-beta -induced invasive phenotype, but also to retain its growth-inhibitory and apoptosis-inducing effects.

引用

页码：S44 / S51

页数：8

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