Practical synthesis of fully-substituted peptide thiazoles

被引：11

作者：

Buchanan, JL ^{[1
]}

Mani, UN ^{[1
]}

Plake, HR ^{[1
]}

Holt, DA ^{[1
]}

机构：

[1] ARIAD Pharmaceut Inc, Cambridge, MA 02139 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 21期

关键词：

thiazoles; amido-ketones; amino acids and derivatives; Grignard reactions reagents;

D O I：

10.1016/S0040-4039(99)00659-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of optically active 2,4,5-substituted 1,3-thiazoles (peptide thiazoles) is described. Both the chirality and the set of side chain functionality in this fully-substituted scaffold are derived from a combination of two amino acids and one organometallic reagent. Preliminary results, with two specific examples, highlight the potential of this strategy for the preparation of a diverse set of building blocks, (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3985 / 3988

页数：4

共 32 条

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