Suppression of BSEP and MRP2 in mouse liver by miroestrol and deoxymiroestrol isolated from Pueraria candollei

被引：18

作者：

Udomsuk, Latiporn ^{[1
,2
]}

Juengwatanatrakul, Thaweesak ^{[3
]}

Putalun, Waraporn ^{[1
,2
]}

Jarukamjorn, Kanokwan ^{[1
,2
]}

机构：

[1] Khon Kaen Univ, Fac Pharmaceut Sci, Acad Off Pharmaceut Sci, Khon Kaen 40002, Thailand

[2] Khon Kaen Univ, Natl Res Univ, Res Grp Pharmaceut Act Nat Prod Using Pharmaceut, Khon Kaen 40002, Thailand

[3] Ubon Ratchathani Univ, Fac Pharmaceut Sci, Div Pharmaceut Chem & Technol, Ubon Ratchathani 34190, Thailand

来源：

PHYTOMEDICINE | 2012年 / 19卷 / 14期

关键词：

Miroestrol; Deoxymiroestrol; BSEP; MRP2; Bile salt export pump; SALT EXPORT PUMP; VAGINAL CORNIFICATION; POSTMENOPAUSAL WOMEN; BILE; MIRIFICA; EXPRESSION; PHYTOESTROGENS; PEROXIDATION; REPLACEMENT; METABOLISM;

D O I：

10.1016/j.phymed.2012.06.007

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Miroestrol and deoxymiroestrol are highly active phytoestrogens isolated from the tuberous root of Pueraria candollei var. mirifica (Leguminosae). Modulatory effects of miroestrol and deoxymiroestrol on the mRNAs of BSEP and MRP2 genes involved in bile salt transportation, in C57BL/6 mice were investigated. In contrast to estradiol, miroestrol and deoxymiroestrol suppressed the expression of BSEP and MRP2 mRNA in both male and female mice. The results suggest for the first time that the use of miroestrol and deoxymiroestrol-containing products as alternative medicines or health supplements should be concerned according to their effects on key genes that regulate the bile salt export pump, which could result in the risk of hepatotoxicity and intrahepatic cholestasis. (C) 2012 Elsevier GmbH. All rights reserved.

引用

页码：1332 / 1335

页数：4

共 28 条

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