Time-dependent effect of tamoxifen therapy on endometrial pathology in asymptomatic postmenopausal breast cancer patients

被引：49

作者：

Cohen, I

Altaras, MM

Shapira, J

Tepper, R

Rosen, DJD

Cordoba, M

Zalel, Y

Figer, A

Yigael, D

Beyth, Y

机构：

[1] SAPIR MED CTR, GYNECOL ONCOL UNIT, IL-44281 KEFAR SAVA, ISRAEL

[2] SAPIR MED CTR, MED ONCOL UNIT, IL-44281 KEFAR SAVA, ISRAEL

[3] SAPIR MED CTR, DEPT PATHOL, IL-44281 KEFAR SAVA, ISRAEL

[4] BEILINSON MED CTR, DEPT ONCOL, PETAH TIQWA, ISRAEL

[5] TEL AVIV UNIV, SACKLER SCH MED, RAMAT AVIV, ISRAEL

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY | 1996年 / 15卷 / 02期

关键词：

endometrium; postmenopausal tamoxifen; long-term treatment;

D O I：

10.1097/00004347-199604000-00010

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Various endometrial lesions were more frequent among asymptomatic postmenopausal breast cancer patients who were treated with tamoxifen for >48 consecutive months (30.8%) when compared with similar patients who were treated for 6-24 months or for 25-48 months (20.8% and 12.5%, respectively). However, this difference was not statistically significant. There were also no significant differences in the frequency of the various endometrial lesions between these three groups, although endometrial polyps were more frequently found among those treated for >48 months. Overall, 20.7% of the 164 tamoxifen-treated patients in the study had an endometrial pathology. It can be concluded that there is a slight tendency among those postmenopausal patients who have been treated for >48 consecutive months to have a higher frequency of endometrial lesions.

引用

页码：152 / 157

页数：6