Strong resistance of oligo(phosphorylcholine) self-assembled monolayers to protein adsorption

被引：86

作者：

Chen, SF

Liu, LY

Jiang, SY ^{[1
]}

机构：

[1] Univ Washington, Dept Chem Engn, Seattle, WA 98195 USA

[2] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

来源：

LANGMUIR | 2006年 / 22卷 / 06期

关键词：

D O I：

10.1021/la052851w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this work, we demonstrate the strong resistance of oligo(phosphoryleholine) (OPC) self-assembled monolayers (SAMs) to protein adsorption and cell adhesion. OPC SAMs were characterized using X-ray photoelectron spectroscopy (XPS), and protein adsorption was measured using a surface plasmon resonance (SPR) sensor. Results are compared with those of phosphoryLcholine (PC) SAMs. Despite the existence of negative charge on OPC SAMs and the simple synthesis procedure of OPC thiols, OPC SAMs resist protein adsorption as effectively as or better than PC SAMs formed from highly purified PC thiols. The ease of their preparation and the effectiveness of their function make OPC SAMs an attractive alternative for creating nonfouling surfaces.

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收藏

页码：2418 / 2421

页数：4

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