Wilms tumor and constitutional epigenetic defects

被引：2

作者：

Riccio, Andrea ^{[1
,2
]}

机构：

[1] Univ Naples 2, Dept Environm Sci, I-81100 Caserta, Italy

[2] CNR, Inst Genet & Biophys A Buzzati Traverso, I-80131 Naples, Italy

来源：

NATURE GENETICS | 2008年 / 40卷 / 11期

关键词：

D O I：

10.1038/ng1108-1272

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Constitutional epigenetic defects affecting the 11p15.5 imprinted region cause a number of syndromic conditions involving birth defects. now, an analysis of a large cohort of individuals with nonsyndromic wilms tumor demonstrates the presence of known and newly identified constitutional IGF2-H19 imprinting defects, extending the phenotype associated with soma-wide 11p15.5 imprinting disorders.

引用

页码：1272 / 1273

页数：2

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