Alternative splicing and genome complexity

被引：364

作者：

Brett, D

Pospisil, H

Valcárcel, J

Reich, J

Bork, P

机构：

[1] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany

[2] European Mol Biol Lab, D-69012 Heidelberg, Germany

来源：

NATURE GENETICS | 2002年 / 30卷 / 01期

关键词：

D O I：

10.1038/ng803

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Alternative splicing of mRNA allows many gene products with different functions to be produced from a single coding sequence. It has recently been proposed as a mechanism by which higher-order diversity is generated. Here we show, using large-scale expressed sequence tag (EST) analysis, that among seven different eukaryotes the amount of alternative splicing is comparable, with no large differences between humans and other animals.

引用

页码：29 / 30

页数：2

共 12 条

[11] SPLIT GENES AND RNA SPLICING
SHARP, PA
[J]. CELL, 1994, 77 (06) : 805 - 815
[12] The sequence of the human genome
Venter, JC
Adams, MD
Myers, EW
Li, PW
Mural, RJ
Sutton, GG
Smith, HO
Yandell, M
Evans, CA
Holt, RA
Gocayne, JD
Amanatides, P
Ballew, RM
Huson, DH
Wortman, JR
Zhang, Q
Kodira, CD
Zheng, XQH
Chen, L
Skupski, M
Subramanian, G
Thomas, PD
Zhang, JH
Miklos, GLG
Nelson, C
Broder, S
Clark, AG
Nadeau, C
McKusick, VA
Zinder, N
Levine, AJ
Roberts, RJ
Simon, M
Slayman, C
Hunkapiller, M
Bolanos, R
Delcher, A
Dew, I
Fasulo, D
Flanigan, M
Florea, L
Halpern, A
Hannenhalli, S
Kravitz, S
Levy, S
Mobarry, C
Reinert, K
Remington, K
Abu-Threideh, J
Beasley, E
[J]. SCIENCE, 2001, 291 (5507) : 1304 - +

← 1 2 →