Interaction between grapefruit juice and praziquantel in humans

被引：31

作者：

Castro, N

Jung, H

Medina, R

González-Esquivel, D

Lopez, M

Sotelo, J

机构：

[1] Inst Nacl Neurol & Neurocirug, Mexico City 14269, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Mexico City 04510, DF, Mexico

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 05期

关键词：

D O I：

10.1128/AAC.46.5.1614-1616.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

After a single oral dose of praziquantel with 250 ml of grapefruit juice, the area under the concentration-time curve and the maximum concentration in plasma of praziquantel (C-max) were significantly increased (C-max for water treatment, 637.71 +/- 128.5 ng/ml; and C-max for grapefruit juice treatment, 1,037.65 +/- 305.7 ng/ml, P < 0.05). No statistically significant differences were found in the time to maximum concentration of drug in plasma or elimination half-life.

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页码：1614 / 1616

页数：3

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