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Monoclonal antibody as therapy for malignant lymphomas

被引：43
作者：
Coiffier, B
机构：
[1] Hospices Civils Lyon, Serv Hematol, F-69495 Pierre Benite, France
[2] Univ Lyon 1, F-69495 Pierre Benite, France
来源：
COMPTES RENDUS BIOLOGIES | 2006年 / 329卷 / 04期
关键词：
rituximab; R-CHOP; follicular lymphoma; diffuse large B-cell lymphoma; radio-labelled antibodies; monoclonal antibodies;
D O I：
10.1016/j.crvi.2005.12.006
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Rituximab was the first monoclonal antibody to have been registered for the treatment of B-cell lymphomas. Randomized studies have demonstrated its activity in follicular lymphoma, mantle-cell lymphoma, and diffuse large B-cell lymphoma in untreated or relapsing patients. Because of its high activity and low toxicity ratio, rituximab has transformed the outcome of patients with B-cell lymphoma. A combination of rituximab plus chemotherapy, R-CHOP has the highest efficacy ever described with any chemotherapy in diffuse large B-cell lymphoma and follicular lymphoma. The role of radio-labelled antibodies is still to be defined.
引用
收藏
页码：241 / 254
页数：14
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