Cytokine gene polymorphisms in Colombian patients with different clinical presentations of tuberculosis

被引:100
作者
Henao, MI [1 ]
Montes, C [1 ]
París, SC [1 ]
García, LF [1 ]
机构
[1] Univ Antioquia, Grp Inmunol Celular & Inmunogenet, Sede Invest Univ, Fac Med, Medellin, Colombia
关键词
tuberculosis; cytokines; polymorphisms; interteukin-10; interferon-gamma;
D O I
10.1016/j.tube.2005.03.001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Tuberculosis (TB) has different clinical presentations. Pulmonary TB affects only the lungs and exhibits variable anti-mycobacterial immune responses. Pleural TB is a localized disease with a strong immune response. Miliary TB is a disseminated form with poor immune response. Cytokines play a pivotal role in anti-mycobacterial response and may determine the type of TB. Thus, gene polymorphisms associated with cytokine production may be associated with clinical presentations of TB. In this study, 54 tuberculin-negative healthy controls, 81 tuberculin-positive healthy controls, 140 patients with pulmonary TB, 30 with pleural TB and 20 with miliary TB were studied. Single nucleotide polymorphisms were typed for tumour necrosis factor-alpha, interferon-gamma (IFN-gamma), transforming growth factor-beta 1, interteukin-10 (IL-10) and interleukin-6 by sequence-specific primer polymerase chain reaction (SSP-PCR). Allelic, genotypic and haplotypic associations with clinical forms of TB were evaluated. IL-10 -1082 A/A genotype and IFN gamma+874 T allele were associated with pleural TB. Seventy-five extended genotypes were found; two differed between patients and controls, and two between groups of patients. Results suggest that IL-10 tow-producer potymorphism and IFN-gamma high-producer polymorphism are associated with pleural TB. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:11 / 19
页数:9
相关论文
共 57 条
[1]   Impact of the-308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease [J].
Abraham, LJ ;
Kroeger, KM .
JOURNAL OF LEUKOCYTE BIOLOGY, 1999, 66 (04) :562-566
[2]   Mendelian susceptibility to mycobacterial infection in man [J].
Altare, F ;
Jouanguy, E ;
Lamhamedi, S ;
Döffinger, R ;
Fischer, A ;
Casanova, JL .
CURRENT OPINION IN IMMUNOLOGY, 1998, 10 (04) :413-417
[3]   The effect of polymorphisms in tumor necrosis factor-α, interleukin-10, and transforming growth factor-β1 genes in acute hepatic allograft rejection [J].
Bathgate, AJ ;
Pravica, V ;
Perrey, C ;
Theraponods, G ;
Plevris, JN ;
Hayes, PC ;
Hutchinson, IV .
TRANSPLANTATION, 2000, 69 (07) :1514-1517
[4]  
Bean AGD, 1999, J IMMUNOL, V162, P3504
[5]   Immunopathologic effects of tumor necrosis factor alpha in murine mycobacterial infection are dose dependent [J].
Bekker, LG ;
Moreira, AL ;
Bergtold, A ;
Freeman, S ;
Ryffel, B ;
Kaplan, G .
INFECTION AND IMMUNITY, 2000, 68 (12) :6954-6961
[6]   Genetic susceptibility to mycobacteria and other infectious pathogens in humans [J].
Bellamy, R ;
Hill, AVS .
CURRENT OPINION IN IMMUNOLOGY, 1998, 10 (04) :483-487
[7]   Cytokine gene polymorphism in human disease: on-line databases [J].
Bidwell, J ;
Keen, L ;
Gallagher, G ;
Kimberly, R ;
Huizinga, T ;
McDermott, MF ;
Oksenberg, J ;
McNicholl, J ;
Pociot, F ;
Hardt, C ;
D'Alfonso, S .
GENES AND IMMUNITY, 1999, 1 (01) :3-19
[8]   Polymorphism of the tumor necrosis factor α gene in patients with infiltrative tuberculosis from the Bashkortostan populations [J].
Bikmaeva, AR ;
Sibiryak, SV ;
Valiakhmetova, DK ;
Khusnutdinova, EK .
MOLECULAR BIOLOGY, 2002, 36 (05) :631-633
[9]  
Bonecini-Almeida MG, 1998, J IMMUNOL, V160, P4490
[10]   IL-10-producing T cells suppress immune responses in anergic tuberculosis patients [J].
Boussiotis, VA ;
Tsai, EY ;
Yunis, EJ ;
Thim, S ;
Delgado, JC ;
Dascher, CC ;
Berezovskaya, A ;
Rousset, D ;
Reynes, JM ;
Goldfeld, AE .
JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (09) :1317-1324