Vitamin C: poison, prophylactic or panacea?

被引:123
作者
Halliwell, B [1 ]
机构
[1] Natl Univ Singapore, Dept Biochem, Singapore 119260, Singapore
关键词
D O I
10.1016/S0968-0004(99)01418-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ascorbate is an essential enzyme cofactor but is often also regarded as an important antioxidant in vivo, protecting against cancer by scavenging DNA-damaging reactive oxygen species. Recent studies suggest that ascorbate some times increases DNA damage in humans. Although there is no evidence that any of these effects are deleterious to humans, we might need to change our thinking about the mechanisms of the antioxidant action of ascorbate in vivo.
引用
收藏
页码:255 / 259
页数:5
相关论文
共 39 条
  • [1] OXIDANTS, ANTIOXIDANTS, AND THE DEGENERATIVE DISEASES OF AGING
    AMES, BN
    SHIGENAGA, MK
    HAGEN, TM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) : 7915 - 7922
  • [2] Beatty Emily R., 1999, Proceedings of the Nutrition Society, V58, p44A
  • [3] BIELSKI BHJ, 1975, ANN NY ACAD SCI, V300, P535
  • [4] VITAMIN-C AND CANCER PREVENTION - THE EPIDEMIOLOGIC EVIDENCE
    BLOCK, G
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1991, 53 (01) : S270 - S282
  • [5] THE PECKING ORDER OF FREE-RADICALS AND ANTIOXIDANTS - LIPID-PEROXIDATION, ALPHA-TOCOPHEROL, AND ASCORBATE
    BUETTNER, GR
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1993, 300 (02) : 535 - 543
  • [6] ENDOGENOUSLY GENERATED ACTIVE OXYGEN SPECIES AND CELLULAR GLUTATHIONE LEVELS IN RELATION TO BHK-21 CELL-PROLIFERATION
    BURDON, RH
    ALLIANGANA, D
    GILL, V
    [J]. FREE RADICAL RESEARCH, 1994, 21 (03) : 121 - 133
  • [7] DETECTION OF ENDOGENOUS MALONDIALDEHYDE-DEOXYGUANOSINE ADDUCTS IN HUMAN LIVER
    CHAUDHARY, AK
    NOKUBO, M
    REDDY, GR
    YEOLA, SN
    MORROW, JD
    BLAIR, IA
    MARNETT, LJ
    [J]. SCIENCE, 1994, 265 (5178) : 1580 - 1582
  • [8] REGIONAL CHARACTERISTICS OF INTESTINAL IRON-ABSORPTION IN THE GUINEA-PIG
    CHOWRIMOOTOO, G
    DEBNAM, ES
    SRAI, SKS
    EPSTEIN, O
    [J]. EXPERIMENTAL PHYSIOLOGY, 1992, 77 (01) : 177 - 183
  • [9] Novel repair action of vitamin C upon in vivo oxidative DNA damage
    Cooke, MS
    Evans, MD
    Podmore, ID
    Herbert, KE
    Mistry, N
    Mistry, P
    Hickenbotham, PT
    Hussieni, A
    Griffiths, HR
    Lunec, J
    [J]. FEBS LETTERS, 1998, 439 (03) : 363 - 367
  • [10] DEMPLE B, 1994, ANNU REV BIOCHEM, V63, P915, DOI 10.1146/annurev.biochem.63.1.915