Disease outcome and cytokine responses in cats immunized with an avirulent feline infectious peritonitis virus (FIPV)-UCD1 and challenge-exposed with virulent FIPV-UCD8

被引:48
作者
Kiss, I
Poland, AM
Pedersen, NC
机构
[1] Vet Inst Debrecen, H-4002 Debrecen, Hungary
[2] Univ Calif Davis, Sch Vet Med, Ctr Compan Anim Hlth, Davis, CA 95616 USA
关键词
D O I
10.1016/j.jfms.2003.08.009
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Eight cats were immunized with an avirulent strain of feline infectious peritonitis virus (FIPV)-UCD1, then challenge-exposed to a highly virulent cat passaged strain (FIPV-UCD8). Th1 and Th2 cytokine profiles in the peripheral blood mononuclear cells (PBMCs) were measured throughout in the experiment. No clinical signs of FIP were evident in the experimental cats after immunization. After challenge, the immunized cats demonstrated one of four clinical outcomes: (1) classical effusive FIP; (2) accelerated FIP; (3) non-effusive FIP, or (4) resistance to challenge. Only minor cytokine changes were observed following immunization, however, several cytokine changes occurred following challenge-exposure. The most noteworthy changes were in tumor necrosis factor-alpha (TNF-alpha) and interferon gamma (IFN-gamma) levels. Our preliminary findings suggest that immunity against FIP is associated with TNF-alpha and IFN-gamma response imbalance, with high TNF-alpha/low IFN-gamma mRNA responses favouring disease and low TNF-alpha/high IFN-gamma mRNA responses being indicative of immunity. (C) 2004 ESFM and AAFP. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:89 / 97
页数:9
相关论文
共 27 条
[21]  
PEDERSEN NC, 1980, AM J VET RES, V41, P868
[22]   Two related strains of feline infectious peritonitis virus isolated from immunocompromised cats infected with a feline enteric coronavirus [J].
Poland, AM ;
Vennema, H ;
Foley, JE ;
Pedersen, NC .
JOURNAL OF CLINICAL MICROBIOLOGY, 1996, 34 (12) :3180-3184
[23]  
REEVES NCP, 1992, CORNELL VET, V82, P117
[24]  
SCOTT FW, 1995, FELINE PRACT, V23, P74
[25]   INTRINSIC RESISTANCE OF FELINE PERITONEAL-MACROPHAGES TO CORONAVIRUS INFECTION CORRELATES WITH INVIVO VIRULENCE [J].
STODDART, CA ;
SCOTT, FW .
JOURNAL OF VIROLOGY, 1989, 63 (01) :436-440
[26]  
Tizard I. R., 2000, VET IMMUNOLOGY INTRO, P276
[27]   Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses [J].
Vennema, H ;
Poland, A ;
Foley, J ;
Pedersen, NC .
VIROLOGY, 1998, 243 (01) :150-157