A family of fibrinogen-related proteins that precipitates parasite-derived molecules is produced by an invertebrate after infection

被引：265

作者：

Adema, CM ^{[1
]}

Hertel, LA ^{[1
]}

Miller, RD ^{[1
]}

Loker, ES ^{[1
]}

机构：

[1] UNIV NEW MEXICO, DEPT BIOL, ALBUQUERQUE, NM 87131 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1997年 / 94卷 / 16期

关键词：

D O I：

10.1073/pnas.94.16.8691

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

After infection with the digenetic trematode Echinostoma paraensei, hemolymph of the snail Biomphalaria. glabrata contains lectins comprised of 65-kDa subunits that precipitate polypeptides secreted by E. paraensei intramolluscan larvae, Comparable activity is lacking in hemolymph of uninfected snails. Three different cDNAs with sequence similarities to peptides derived from the 65-kDa lectins were obtained and unexpectedly found to encode fibrinogen-related proteins (FREPs). These FREPs also contained regions with sequence similarity to Ig superfamily members, B. glabrata has at least five FREP genes, three of which are expressed at increased levels after infection, Elucidation of components of the defense system of B. glabrata is relevant because this snail is an intermediate host for Schistosoma mansoni, the most widely distributed causative agent of human schistosomiasis. These results are novel in suggesting a role for invertebrate FREPs in recognition of parasite-derived molecules and also provide a model for investigating the diversity of molecules functioning in nonself-recognition in an invertebrate.

引用

页码：8691 / 8696

页数：6

共 26 条

[11]

Kurosawa Y., 1996, Advances in Comparative and Environmental Physiology, V23, P151

[12] The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults [J].