Bioactive constituents of Chinese natural medicines.: VII.: Inhibitors of degranulation in RBL-2H3 cells and absolute stereo structures of three new diarylheptanoid glycosides from the bark of a Myrica rubra

被引：97

作者：

Matsuda, H ^{[1
]}

Morikawa, T ^{[1
]}

Tao, J ^{[1
]}

Ueda, K ^{[1
]}

Yoshikawa, M ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078412, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2002年 / 50卷 / 02期

关键词：

Myrica rubra; degranulation inhibitor; RBL-2H3; cell; (+)-S-myricanol 5-O-beta-D-glucopyranoside; myricanene A 5-O-alpha-L-arabinofuranosyl(l -> 6)-beta-D-glucopyranoside; myricanene B5-O-alpha-L-arabinofuranosyl(l -> 6)-beta-D-glucopyranoside;

D O I：

10.1248/cpb.50.208

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Three new diarylheptanoid glycosides, named (+)-S-myricanol 5-O-beta-D-glucopyranoside, myricanene A 5-O-alpha-L-arabinofuranosyl(1-->6)-beta-D-glucopyranoside, and myricanene B 5-O-alpha-L-arabinofuranosyl(1-->6)-beta-D-glucopyranoside, were Isolated from the bark of Chinese Myrica rubra, together with twenty known compounds. The absolute stereostructures of the new diarylheptanoid glycosides were elucidated on the basis of chemical and physicochemical evidence, including the application of the modified Mosher's method. The inhibitory effects of isolated constituents on the release of beta-hexosaminidase from RBL-2H3 cells were examined, and several diaryl-heptanoids, myricanol, (+)-S-myricanol, myricanone, and myricanenes A and B, and a flavonol, myricetin, were found to show the inhibitory activity.

引用

页码：208 / 215

页数：8

共 60 条

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