The PPD-specific T-cell clonal response in UK and Malawian subjects following BCG vaccination: A new repertoire evolves over 12 months

被引：9

作者：

Bennett, AR

Gorak-Stolinska, P

Ben-Smith, A

Floyd, S

de Lara, CM

Weir, RE

Lalor, MK

Makamo, K

Msiska, GK

Crampin, AC

Fine, PEM

Dockrell, HM

Beverley, PCL ^{[1
]}

机构：

[1] Edward Jenner Inst Vaccine Res, Compton RG20 7NN, Berks, England

[2] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England

[3] Karonga Prevent Study, Chilumba, Malawi

来源：

VACCINE | 2006年 / 24卷 / 14期

基金：

英国惠康基金;

关键词：

BCG; immunisation; clonality; Mycobacterium tuberculosis;

D O I：

10.1016/j.vaccine.2005.12.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mycobacterium bovis bacille Calmette Guerin vaccination protects against pulmonary tuberculosis in the United Kingdom but not in Malawi. We investigated whether a difference in the clonal T-cell response to BCG vaccination might account for this. The results of clonal analysis were compared to those obtained by skin testing and in a whole blood interferon gamma assay. Pre-vaccination antigen specific T-cell clones were detected, but the majority of clones present 12 months after vaccination were not present earlier. The magnitude of the clonal response did not correlate well with results of the other assays. These data indicate that single assays may not be reliable and that a stable memory T-cell repertoire is slow to develop. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2617 / 2626

页数：10

共 34 条

[31] Age-related modifications of the human αβ T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets [J].