The parallel synthesis of peptide based phosphine ligands

被引：68

作者：

Gilbertson, SR ^{[1
]}

Wang, XF ^{[1
]}

机构：

[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA

来源：

TETRAHEDRON | 1999年 / 55卷 / 39期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4020(99)00682-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemistry is reported that allows for the synthesis and screening of phosphine ligands by standard combinatorial technology. To demonstrate the method, libraries of phosphine containing peptides were synthesized, Rhodium was complexed to the phosphine ligands while they were attached to the synthesis support. Each member of the library was screened for its ability to catalyze the asymmetric hydrogenation of enamides. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：11609 / 11618

页数：10

共 19 条

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