Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity

被引：126

作者：

Saito, Takeshi ^{[1
]}

Gale, Michael, Jr. ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Dept Immunol, Seattle, WA 98195 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2008年 / 205卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1084/jem.20081210

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Retinoic acid-inducible gene (RIG)-I-like receptors (RLRs) are cytosolic RNA helicases that sense viral RNA and trigger signaling pathways that induce the production of type I interferons (IFNs) and proinflammatory cytokines. RLRs recognize distinct and overlapping sets of viruses, but the mechanisms that dictate this specificity were unknown. A new study now provides evidence for size-based discrimination of double-stranded RNA (dsRNA) by RLRs and suggests how host cells recognize a variety of RNA viruses.

引用

页码：1523 / 1527

页数：5

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