HIV-1 Reverse Transcriptase: A therapeutical target in the spotlight

被引：54

作者：

Castro, HC

Loureiro, NIV

Pujol-Luz, M

Souza, AMT

Albuquerque, MG

Santos, DO

Cabral, LM

Frugulhetti, IC

Rodrigues, CR

机构：

[1] Univ Fed Fluminense, Dept Biol Celular & Mol, IB, Lab Bioquim & Modelagem Mol LaBioMol, BR-24001970 Niteroi, RJ, Brazil

[2] Univ Fed Rio de Janeiro, Dept Quim Organ, IQ, Lab Modelagem Mol LabMMol, BR-21949900 Rio De Janeiro, Brazil

[3] Univ Fed Fluminense, Dept Biol Celular & Mol, IB, Mol Virol Lab, BR-24001970 Niteroi, RJ, Brazil

[4] Univ Fed Rio de Janeiro, Fac Farm, DLab Modelagem Mol & QSAR ModMolQSAR, BR-21941590 Rio De Janeiro, Brazil

来源：

CURRENT MEDICINAL CHEMISTRY | 2006年 / 13卷 / 03期

关键词：

reverse transcriptase; nucleoside; nucleotide; non-nucleoside; DNA; RNA; antiretroviral; AIDS;

D O I：

10.2174/092986706775476089

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human Immunodeficiency Virus type 1 Reverse Transcriptase (HIV-1 RT) is one of the most important targets for treatment of Acquired Immune Deficiency Syndrome (AIDS). It catalyzes the reverse transcription of HIV-RNA into a double stranded DNA, and the knowledge of its substrate specificity and catalytic mechanism has guided the development of several inhibitors widely used on current HIV/AIDS therapy. However, mutations in HIV-1 RT structure can lead to the emergence of drug-resistant virus strains. The goal of this review is to summarize relevant structural features of HIV-1 RT and its inhibitors in such a way that this cost-effective target in the development of new antiretroviral drugs is particularly highlighted.

引用

页码：313 / 324

页数：12

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