Significance of E-cadherin, β-catenin, and vimentin expression as postoperative prognosis indicators in cervical squamous cell carcinoma

被引：149

作者：

Cheng, Yong ^{[2
]}

Zhou, Ying ^{[1
]}

Jiang, Wenjing ^{[1
]}

Yang, Xia ^{[1
]}

Zhu, Jing ^{[1
]}

Feng, Dingqing ^{[1
]}

Wei, Ying ^{[1
]}

Li, Min ^{[1
]}

Yao, Fengqiu ^{[1
]}

Hu, Weiping ^{[1
]}

Xiao, Weihua ^{[3
,4
]}

Ling, Bin ^{[1
]}

机构：

[1] Anhui Med Univ, Anhui Prov Hosp, Dept Obstet & Gynecol, Hefei 230001, Peoples R China

[2] Anhui Med Univ, Anhui Prov Hosp, Dept Oncol Radiotherapy, Hefei 230001, Peoples R China

[3] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China

[4] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China

来源：

HUMAN PATHOLOGY | 2012年 / 43卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Vimentin; E-cadherin; beta-Catenin; Cervical cancer; EPITHELIAL-MESENCHYMAL-TRANSITION; COLORECTAL-CANCER PROGRESSION; UP-REGULATION; EMT; FEATURES; COMPLEX; TRANSFORMATION; ASSOCIATION; ACTIVATION; PATHWAYS;

D O I：

10.1016/j.humpath.2011.08.025

中图分类号：

R36 [病理学];

学科分类号：

100103 [病原生物学];

摘要：

Although early-stage cervical cancer can be treated by surgery, distant metastases can be life threatening. It has been a challenge to identify reliable biomarkers as indicators of metastasis or poor prognosis. We investigated the prognostic impact of vimentin, E-cadherin, and beta-catenin expression measured by immunohistochemistry staining in samples from 135 patients with clinical stage I or II cervical squamous cell cancer and in normal cervical tissues from 55 patients who underwent hysterectomy for reasons other than neoplasia. Down-regulation of E-cadherin and beta-catenin was positively related to histologic differentiation (P < .001), metastasis (P < .001), and recurrence (P < .001), whereas up-regulation of vimentin was inversely related to histologic differentiation, metastasis, and recurrence (P < .0001, .020, and .000, respectively). In univariate Cox regression analysis, high expression of E-cadherin or beta-catenin was a positive prognostic indicator for overall survival (P < .001 and P < .001, respectively), whereas high expression of vimentin was a negative indicator (P < .001). In multivariate Cox regression analysis, high expression of E-cadherin was a positive prognostic indicator for overall survival (P = .002), whereas high expression of vimentin was a negative indicator (P = .034). The expression of E-cadherin and vimentin was associated with survival, and the 2 proteins were independent prognostic factors in univariate and multivariate analyses. The combination of a decrease of E-cadherin and an increase in vimentin might be a valuable survival indictor in cervical squamous cell cancer. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：1213 / 1220

页数：8

共 26 条

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The prognostic impact of NF-κB p105, vimentin, E-cadherin and Par6 expression in epithelial and stromal compartment in non-small-cell lung cancer [J].