Pharmacological induction of tolerogenic dendritic cells and regulatory T cells

被引：176

作者：

Adorini, L ^{[1
]}

Giarratana, N ^{[1
]}

Penna, G ^{[1
]}

机构：

[1] BioXell, I-20132 Milan, Italy

来源：

SEMINARS IN IMMUNOLOGY | 2004年 / 16卷 / 02期

关键词：

tolerogenic dentritic cell; pharmacological induction; regulatory T cell; vitamin D-3 analogs;

D O I：

10.1016/j.smim.2003.12.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunosuppressive and anti-inflammatory agents are able to generate tolerogenic DCs, leading, in some cases, to induction or enhancement of regulatory T cells with suppressive activity. This novel mechanism of action, shared by several immunosuppressive and anti-inflammatory agents, is becoming firmly established and contributes to explain their functional properties. The possibility to manipulate DCs in vivo using more or less conventional low molecular weight drugs, enabling them to exert tolerogenic activities, could be exploited to better control a variety of chronic inflammatory conditions, from autoimmune diseases to allograft rejection. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：127 / 134

页数：8

共 68 条

[1] Interleukin-12, a key cytokine in Th1-mediated autoimmune diseases [J].