Helicobacter pylori primary resistance to metronidazole and clarithromycin in Brazil

被引：44

作者：

Magalhaes, PP

Queiroz, DMD

Barbosa, DVC

Rocha, GA

Mendes, EN

Santos, A

Corrêa, PRV

Rocha, AMC

Teixeira, LM

de Oliveira, CA

机构：

[1] UFMG, Fac Med, Lab Bacteriol, BR-30130100 Belo Horizonte, MG, Brazil

[2] Univ Itauna, Fac Fisioterapia, Itauna, MG, Brazil

[3] Univ Fed Rio de Janeiro, Inst Microbiol, Rio De Janeiro, Brazil

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 06期

关键词：

D O I：

10.1128/AAC.46.6.2021-2023.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Helicobacter pylori resistance to metronidazole was detected in 107 (52.97%) of 202 strains. Twenty (9.85%) strains, IS of them harboring 23S ribosomal DNA mutations, were resistant to clarithromycin. Metronidazole resistance was associated with female gender. Resistance to metronidazole and resistance to clarithromycin were associated. Increasing clarithromycin resistance rates were observed over time.

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页码：2021 / 2023

页数：3

相关论文

共 30 条

[21]

2-#

[22]

QUEIROZ DMM, 1993, AM J GASTROENTEROL, V88, P322

[23] Susceptibility of Helicobacter pylori to metronidazole in a Brazilian population [J].

Salazar, M ;

Abalem, I ;

Solari, C ;

Rodriguez, C ;

Luna, L .

MEMORIAS DO INSTITUTO OSWALDO CRUZ, 1996, 91 (06) :777-778

[24] Metronidazole activation is mutagenic and causes DNA fragmentation in Helicobacter pylori and in Escherichia coli containing a cloned H. pylori rdxA plus (nitroreductase) gene [J].

Sisson, G ;

Jeong, JY ;

Goodwin, A ;

Bryden, L ;

Rossler, N ;

Lim-Morrison, S ;

Raudonikiene, A ;

Berg, DE ;

Hoffman, PS .

JOURNAL OF BACTERIOLOGY, 2000, 182 (18) :5091-5096

[25] Increasing multidrug resistance in Helicobacter pylori strains isolated from children and adults in Mexico [J].

Torres, J ;

Camorlinga-Ponce, M ;

Pérez-Pérez, G ;

Madrazo-De la Garza, A ;

Dehesa, M ;

González-Valencia, G ;

Munoz, O .

JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (07) :2677-2680

[26] Accurate prediction of macrolide resistance in Helicobacter pylori by a PCR line probe assay for detection of mutations in the 23S rRNA gene:: Multicenter validation study [J].

van Doorn, LJ ;

Glupczynski, Y ;

Kusters, JG ;

Mégraud, F ;

Midolo, P ;

Maggi-Solcà, N ;

Queiroz, DMM ;

Nouhan, N ;

Stet, E ;

Quint, WGV .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (05) :1500-1504

[27]

vanZwet AA, 1996, EUR J CLIN MICROBIOL, V15, P861, DOI 10.1007/BF01691216

[28] Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance [J].

Versalovic, J ;

Osato, MS ;

Spakovsky, K ;

Dore, MP ;

Reddy, R .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 40 (02) :283-286

[29] Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori [J].

Versalovic, J ;

Shortridge, D ;

Kibler, K ;

Griffy, MV ;

Beyer, J ;

Flamm, RK ;

Tanaka, SK ;

Graham, DY ;

Go, MF .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (02) :477-480

[30] Multiplex sequence analysis demonstrates the competitive growth advantage of the A-to-G mutants of clarithromycin-resistant Helicobacter pylori [J].

Wang, G ;

Rahman, MS ;

Humayun, MZ ;

Taylor, DE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (03) :683-685