An efficient synthesis of a fully functionalized 7-aminoaziridinomitosene

被引：17

作者：

Edstrom, ED ^{[1
]}

Yu, T ^{[1
]}

机构：

[1] UTAH STATE UNIV,DEPT CHEM & BIOCHEM,LOGAN,UT 84322

来源：

TETRAHEDRON | 1997年 / 53卷 / 13期

关键词：

D O I：

10.1016/S0040-4020(97)00173-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient approach for the synthesis of a fully functionalized 7-aminoaziridinomitosene has been developed Commencing with the known 2,3,5,6,7,8-hexahydro-8-oxo-1H-pyrrolo[1,2-a]indole 6, twelve transformations leads to the novel 7-amimoaziridinomitosene 4 in 11% overall yield. This study demonstrates the feasibility of installing the free aziridine and the aminoquinone functionalities on the pyrrolo[1,2a]indole skeleton. (C) 1997 Elsevier Science Ltd.

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页码：4549 / 4560

页数：12

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