Simultaneous determination of caffeine and non-steroidal anti-inflammatory drugs in pharmaceutical formulations and blood plasma by reversed-phase HPLC from linear gradient elution

被引：77

作者：

Martín, MJ ^{[1
]}

Pablos, F ^{[1
]}

González, AG ^{[1
]}

机构：

[1] Univ Seville, Dept Analyt Chem, E-41012 Seville, Spain

来源：

TALANTA | 1999年 / 49卷 / 02期

关键词：

high performance liquid chromatography; non-steroidal anti-inflammatories; blood plasma; pharmaceutical preparations;

D O I：

10.1016/S0039-9140(99)00006-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A reversed-phase HPLC procedure based on methanol-water gradient elution for determining caffeine and non-steroidal anti-inflammatory drugs with UV absorbance detection is proposed. Chromatographic operational conditions were selected by considering the peak resolution and the retention times of the first and last eluted compounds. The method was suitably validated and successfully applied to the determination of: caffeine, indoprofen, ketoprofen, naproxen, fenbufen and ibuprofen in blood plasma samples and several analgesic/antiphlogistic pharmaceutical formulations. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

引用

页码：453 / 459

页数：7

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