Ionization constants of water insoluble arylpropionic acids in aqueous N,N-dimethylformamide mixtures from potentiometric pH-titrations

被引：21

作者：

González, AG ^{[1
]}

Herrador, MA ^{[1
]}

机构：

[1] Univ Seville, Dept Analyt Chem, E-41012 Seville, Spain

来源：

ANALYTICA CHIMICA ACTA | 1997年 / 356卷 / 2-3期

关键词：

water N; N-dimethylformamide mixtures; arylpropionic acids; partially aqueous pH titrations; poorly water soluble drugs;

D O I：

10.1016/S0003-2670(97)00545-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The ionization constants of five water insoluble anti-inflammatory arylpropionicacids were evaluated in 80% VN N,N-dimethylformamide aqueous mixture. From these values, data on proton dissociation constants in water have been computed and compared with the results previously reported by using different approaches. (C) 1997 Elsevier Science B.V.

引用

页码：253 / 258

页数：6

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