Effects of ibuprofen and indomethacin on the regional circulation in newborn piglets

被引:32
作者
Speziale, MV [1 ]
Allen, RG [1 ]
Henderson, CR [1 ]
Barrington, KJ [1 ]
Finer, NN [1 ]
机构
[1] Univ Calif San Diego, Dept Pediat, San Diego, CA 92103 USA
来源
BIOLOGY OF THE NEONATE | 1999年 / 76卷 / 04期
关键词
nonsteroidal anti-inflammatory drug; renal perfusion; gastrointestinal perfusion; cerebral perfusion; blood flow;
D O I
10.1159/000014165
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
We investigated the effects of clinically comparable doses of ibuprofen and indomethacin on renal, gastrointestinal and cerebral perfusion in newborn piglets, and hypothesized that ibuprofen would have less effect on regional circulation. Animals were randomly assigned to receive ibuprofen (20 mg/kg, n = 8), indomethacin (0.3 mg/kg, n = 7) or vehicle (n = 6). Fluorescent microspheres were injected prior to and at 20, 40, 60, 90 and 120 min after drug administration. Regional blood flow was measured and vascular resistances were calculated. Cardiovascular and respiratory variables were not significantly affected by either study drug or vehicle. Ibuprofen increased renal cortical and medullary resistance by 44 and 52% (p < 0.05). However, ibuprofen had no significant effects on gastrointestinal or cerebral resistance. Indomethacin raised renal cortical and medullary resistance by 66 and 71% at 60 min postinjection, respectively (p < 0.05). Indomethacin increased duodenojejunal, ileal and colon resistance by 97, 102 and 75% at 60 min, respectively (p < 0.05). Indomethacin increased cerebral cortical and cerebellar resistance by 92 and 86% at 90 min (p < 0.05). While indomethacin and, to a lesser extent, ibuprofen both increase renal vascular resistance, indomethacin vasoconstricts the gastrointestinal and cerebral circulations which are unaffected by ibuprofen.
引用
收藏
页码:242 / 252
页数:11
相关论文
共 48 条
[1]   LOCALIZED INTESTINAL PERFORATIONS AFTER ENTERAL ADMINISTRATION OF INDOMETHACIN IN PREMATURE-INFANTS [J].
ALPAN, G ;
EYAL, F ;
VINOGRAD, I ;
UDASSIN, R ;
AMIR, G ;
MOGLE, P ;
GLICK, B .
JOURNAL OF PEDIATRICS, 1985, 106 (02) :277-281
[2]  
ARANDA JV, 1993, J LIPID MEDIATOR, V6, P493
[3]   PREDICTING OLIGURIA FOLLOWING INDOMETHACIN FOR TREATMENT OF PATENT DUCTUS-ARTERIOSUS [J].
BARRINGTON, KJ ;
FOX, M .
AMERICAN JOURNAL OF PERINATOLOGY, 1994, 11 (03) :220-222
[4]  
BETKERUR MV, 1981, PEDIATRICS, V68, P99
[5]   DIFFERENCES IN THE EFFECTS IN THE NEWBORN PIGLET OF VARIOUS NONSTEROIDAL ANTIINFLAMMATORY DRUGS ON CEREBRAL BLOOD-FLOW BUT NOT ON CEREBROVASCULAR PROSTAGLANDINS [J].
CHEMTOB, S ;
BEHARRY, K ;
BARNA, T ;
VARMA, DR ;
ARANDA, JV .
PEDIATRIC RESEARCH, 1991, 30 (01) :106-111
[6]   PROSTANOIDS DETERMINE THE RANGE OF CEREBRAL BLOOD-FLOW AUTOREGULATION OF NEWBORN PIGLETS [J].
CHEMTOB, S ;
BEHARRY, K ;
REX, J ;
VARMA, DR ;
ARANDA, JV .
STROKE, 1990, 21 (05) :777-784
[7]  
CHENTOB S, 1990, PEDIATR RES, V27, pA57
[8]   INDOMETHACIN AND RENAL-FUNCTION IN PREMATURE-INFANTS WITH PERSISTENT PATENT DUCTUS-ARTERIOSUS [J].
CIFUENTES, RF ;
OLLEY, PM ;
BALFE, JW ;
RADDE, IC ;
SOLDIN, SJ .
JOURNAL OF PEDIATRICS, 1979, 95 (04) :583-587
[9]   EFFECT OF INFUSION RATE OF INDOMETHACIN ON CEREBROVASCULAR RESPONSES IN PRETERM NEONATES [J].
COLDITZ, P ;
MURPHY, D ;
ROLFE, P ;
WILKINSON, AR .
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 1989, 64 (01) :8-12
[10]   GUT BLOOD-FLOW VELOCITIES IN THE NEWBORN - EFFECTS OF PATENT DUCTUS-ARTERIOSUS AND PARENTERAL INDOMETHACIN [J].
COOMBS, RC ;
MORGAN, MEI ;
DURBIN, GM ;
BOOTH, IW ;
MCNEISH, AS .
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 1990, 65 (10) :1067-1071