Template Control over Dimerization and Guest Selectivity of Interpenetrated Coordination Cages

We have previously shown that the self-assembly of dibenzosuberone-based bis-monodentate pyridyl ligands L-1 with Pd-11 cations leads to the quantitative formation of interpenetrated coordination cages [BF4@Pd4L81]. The BF4- anion inside the central cavity serves as a template, causing the outer two pockets to show a tremendous affinity for allosteric binding of two small chloride anions. Here we show that derivatization of the ligand backbone with a bulky aryl substituent allows us to control the dimerization and hence the guest binding ability of the cage by the choice of the templating anion. Steric constraints imposed by L-2 prevent the large BF4- anion from serving as a template for the formation of interpenetrated double cages. Instead, a single isomer of the monomeric cage [Pd2L42] is formed. Addition of the small anionic template Cl- permits dimerization, yielding the interpenetrated double cage [Cl@Pd4L82], whose enlarged outer pockets show a preference for the binding of large anions such as ReO4-.