Genetic structure of Candida glabrata populations in AIDS and non-AIDS patients

被引：26

作者：

de Meeûs, T

Renaud, F

Mouveroux, E

Reynes, J

Galeazzi, G

Mallié, M

Bastide, JM

机构：

[1] Fac Pharm Montpellier, Lab Immunol & Parasitol, F-34060 Montpellier 1, France

[2] CNRS IRD, UMR 9926, Ctr Etud Polymorphisme Microorganismes, F-34000 Montpellier, France

[3] Hop Gui De Chauliac, Clin Malad Infect A, F-34000 Montpellier, France

[4] Hop Louis Mourier, Unite Parasitol Mycol, F-92700 Colombes, France

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2002年 / 40卷 / 06期

关键词：

D O I：

10.1128/JCM.40.6.2199-2206.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The genotypes of 63 strains (11 reference strains and 52 strains from hospitalized patients) of the haploid yeast Candida glabrata were determined from 33 putative gene enzymatic loci. This enabled the characterization of 26 different multilocus genotypes. Genetic differentiation was found between distant hospitals (located in Montpellier and Paris, France) but not for other parameters (anatomic origins or human immunodeficiency virus-positive [HIV+] and HIV- patients). Strong nonrandom association between loci could be seen. Such statistical linkages were confirmed upon comparing the patterns of 14 RAPD [random(ly) amplified polymorphic DNA] primers from 20 of these strains to results obtained from multilocus enzyme electrophoresis analysis. This finding suggests a mainly clonal mode of reproduction of C. glabrata. The consequences of the clonality displayed by C. glabrata populations on the epidemiology of this yeast are also discussed.

引用

页码：2199 / 2206

页数：8

共 48 条

[41] A CLONAL THEORY OF PARASITIC PROTOZOA - THE POPULATION STRUCTURES OF ENTAMOEBA, GIARDIA, LEISHMANIA, NAEGLERIA, PLASMODIUM, TRICHOMONAS, AND TRYPANOSOMA AND THEIR MEDICAL AND TAXONOMICAL CONSEQUENCES [J].