Intervertebral Disk Nutrition: A Review of Factors Influencing Concentrations of Nutrients and Metabolites

被引：274

作者：

Grunhagen, Thijs ^{[1
,2
]}

Shirazi-Adl, Aboulfazl ^{[3
]}

Fairbank, Jeremy C. T. ^{[4
]}

Urban, Jill P. G. ^{[1
]}

机构：

[1] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3QX, England

[2] Philips Res, NL-5656 AE Eindhoven, Netherlands

[3] Ecole Polytech, Montreal, PQ H3C 3A7, Canada

[4] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford OX3 7LD, England

来源：

ORTHOPEDIC CLINICS OF NORTH AMERICA | 2011年 / 42卷 / 04期

关键词：

Oxygen; Glucose; Diffusion; pH; End plate; Calcification; Intervertebral; Disk; VERTEBRAL END-PLATE; ISSLS PRIZE WINNER; LOW-BACK-PAIN; HUMAN LUMBAR DISCS; IN-VIVO; CELL TRANSPLANTATION; TRANSPORT-PROPERTIES; OXYGEN CONCENTRATION; COUPLED DIFFUSION; CIGARETTE-SMOKING;

D O I：

10.1016/j.ocl.2011.07.010

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

The biomechanical behavior of the intervertebral disk ultimately depends on the viability and activity of a small population of resident cells that make and maintain the disk's extracellular matrix. Nutrients that support these cells are,,,supplied by the blood vessels at the disks' margins and diffuse through the matrix of the avascular disk to the cells. This article reviews pathways of nutrient supply to these cells; examines factors that may interrupt these pathways, and discusses consequences for disk cell survival, disk degeneration, and disk repair.

引用

页码：465 / +

页数：14

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