Crystallization of globular proteins

被引：107

作者：

Poon, WCK

机构：

[1] Department of Physics and Astronomy, University of Edinburgh, Edinburgh, EH9 3JZ, Mayfield Road

来源：

PHYSICAL REVIEW E | 1997年 / 55卷 / 03期

关键词：

D O I：

10.1103/PhysRevE.55.3762

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

Globular proteins can be crystallized by the addition of electrolyte or nonadsorbing polymer. Too much additive, however, gives rise to amorphous precipitates. By comparing existing data on various proteins with previous work on a model colloid-polymer mixture, we suggest an explanation for noncrystallization in terms of a hidden gas-liquid binodal inside the equilibrium fluid-crystal region of the phase diagram.

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页码：3762 / 3764

页数：3

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