Reversal of drug-induced anticoagulation: old solutions and new problems

被引：49

作者：

Dzik, Walter 'Sunny' ^{[1
]}

机构：

[1] J224 Massachusetts Gen Hosp, Blood Transfus Serv, 55 Fruit St, Boston, MA 02114 USA

来源：

TRANSFUSION | 2012年 / 52卷

关键词：

PROTHROMBIN COMPLEX CONCENTRATE; RECOMBINANT FACTOR VIIA; FRESH-FROZEN PLASMA; WARFARIN-ASSOCIATED COAGULOPATHY; INTERNATIONAL NORMALIZED RATIO; EMERGENCY REVERSAL; VITAMIN-K; DABIGATRAN; THROMBIN; THERAPY;

D O I：

10.1111/j.1537-2995.2012.03690.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Anticoagulant drugs are taken by millions of patients throughout the world. Warfarin has been the most widely prescribed anticoagulant for decades. In recent years, new oral anticoagulants have been approved for use, are being positioned as alternatives to warfarin, and represent an enormous market opportunity for pharmaceutical companies. Requests for urgent reversal of anticoagulants are not uncommon especially in the setting of critical bleeding. This review summarizes information on reversal of warfarin by vitamin K, plasma, prothrombin complex concentrates, and recombinant VIIa. In addition, we emphasize the lack of current evidence supporting reversibility of the new oral direct thrombin inhibitors and Factor Xa inhibitors. This review is presented to assist transfusion medicine specialists, hematologists, and other clinicians who prescribe blood components for reversal of drug-induced anticoagulation.

引用

页码：45S / 55S

页数：11

共 41 条

[11] Reversal of Rivaroxaban and Dabigatran by Prothrombin Complex Concentrate A Randomized, Placebo-Controlled, Crossover Study in Healthy Subjects [J].

Eerenberg, Elise S. ;

Kamphuisen, Pieter W. ;

Sijpkens, Meertien K. ;

Meijers, Joost C. ;

Buller, Harry R. ;

Levi, Marcel .

CIRCULATION, 2011, 124 (14) :1573-1579

[12] Anaphylactoid reactions to vitamin K [J].

Fiore, LD ;

Scola, MA ;

Cantillon, CE ;

Brophy, MT .

JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2001, 11 (02) :175-183

[13] EMERGENCY REVERSAL OF ANTICOAGULATION AFTER INTRACEREBRAL HEMORRHAGE [J].

FREDRIKSSON, K ;

NORRVING, B ;

STROMBLAD, LG .

STROKE, 1992, 23 (07) :972-977

[14]

Garber ST, 2012, J NEUROSURG 0306

[15] Timing of fresh frozen plasma administration and rapid correction of coagulopathy in warfarin-related intracerebral hemorrhage [J].

Goldstein, JN ;

Thomas, SH ;

Frontiero, V ;

Joseph, A ;

Engel, C ;

Snider, R ;

Smith, EE ;

Greenberg, SM ;

Rosand, J .

STROKE, 2006, 37 (01) :151-155

[16] How I treat warfarin-associated coagulopathy in patients with intracerebral hemorrhage [J].

Goodnough, Lawrence Tim ;

Shander, Aryeh .

BLOOD, 2011, 117 (23) :6091-6099

[17] Apixaban versus Warfarin in Patients with Atrial Fibrillation [J].

Granger, Christopher B. ;

Alexander, John H. ;

McMurray, John J. V. ;

Lopes, Renato D. ;

Hylek, Elaine M. ;

Hanna, Michael ;

Al-Khalidi, Hussein R. ;

Ansell, Jack ;

Atar, Dan ;

Avezum, Alvaro ;

Cecilia Bahit, M. ;

Diaz, Rafael ;

Easton, J. Donald ;

Ezekowitz, Justin A. ;

Flaker, Greg ;

Garcia, David ;

Geraldes, Margarida ;

Gersh, Bernard J. ;

Golitsyn, Sergey ;

Goto, Shinya ;

Hermosillo, Antonio G. ;

Hohnloser, Stefan H. ;

Horowitz, John ;

Mohan, Puneet ;

Jansky, Petr ;

Lewis, Basil S. ;

Luis Lopez-Sendon, Jose ;

Pais, Prem ;

Parkhomenko, Alexander ;

Verheugt, Freek W. A. ;

Zhu, Jun ;

Wallentin, Lars .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (11) :981-992

[18] Bleeding Risk with Dabigatran in the Frail Elderly [J].

Harper, Paul ;

Young, Laura ;

Merriman, Eileen .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (09) :864-866

[19] Evidence-Based Management of Anticoagulant Therapy Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines [J].

Holbrook, Anne ;

Schulman, Sam ;

Witt, Daniel M. ;

Vandvik, Per Olav ;

Fish, Jason ;

Kovacs, Michael J. ;

Svensson, Peter J. ;

Veenstra, David L. ;

Crowther, Mark ;

Guyatt, Gordon H. .

CHEST, 2012, 141 (02) :E152S-E184S

[20] Suboptimal effect of a three-factor prothrombin complex concentrate (Profilnine-SD) in correcting supratherapeutic international normalized ratio due to warfarin overdose [J].

Holland, Lorne ;

Warkentin, Theodore E. ;

Refaai, Majed ;

Crowther, Mark A. ;

Johnston, Marilyn A. ;

Sarode, Ravindra .

TRANSFUSION, 2009, 49 (06) :1171-1177

← 1 2 3 4 5 →