Genetic analysis of adrenal absence: agenesis and aplasia

被引：55

作者：

Else, T ^{[1
]}

Hammer, GD ^{[1
]}

机构：

[1] Univ Michigan, Dept Internal Med, Div Metab, Ann Arbor, MI 48109 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2005年 / 16卷 / 10期

关键词：

D O I：

10.1016/j.tem.2005.10.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The adrenal cortex shares a common embryological heritage with the gonad and kidney: all are derived from components of the urogenital ridge. Adrenocortical specification from this embryonic structure and the ultimate organogenesis of the adrenal gland are directed by the sequential expression of transcriptional regulators, with later development being additionally mediated by endocrine hormones that regulate organ maintenance and tissue differentiation. Recent advancements in the field of human and mouse genetics have accumulated evidence for a host of novel factors involved in these processes, such as the hedgehog signaling network and peptides derived from proopiomelanocortin.

引用

页码：458 / 468

页数：11

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