Graft copolymers of poly(ethylene glycol) (PEG) and chitosan

被引：45

作者：

Saito, H ^{[1
]}

Wu, XD ^{[1
]}

Harris, JM ^{[1
]}

Hoffman, AS ^{[1
]}

机构：

[1] UNIV ALABAMA,DEPT CHEM,HUNTSVILLE,AL 35899

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 1997年 / 18卷 / 07期

关键词：

D O I：

10.1002/marc.1997.030180703

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Graft copolymers of poly(ethylene glycol) (PEG) on a chitosan backbone (PEG-g-chitosan) have been synthesized and their aqueous solution properties were investigated. At pH 6.5 the graft copolymers are 100% soluble, while chitosan phase separates from solution at those conditions. These interesting graft copolymers may be especially suitable as carriers for delivery of anionic drugs, such as proteins, glycosaminoglycans, and DNA plasmids or oligonucleotides.

引用

页码：547 / 550

页数：4

共 16 条

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