Preparation and properties of modified chitosan films for drug release

被引：53

作者：

Angelova, N

Manolova, N

Rashkov, I

Maximova, V

Bogdanova, S

Domard, A

机构：

[1] BULGARIAN ACAD SCI,INST POLYMERS,BU-1113 SOFIA,BULGARIA

[2] BULGARIAN ACAD SCI,INST MOLEC BIOL,BU-1113 SOFIA,BULGARIA

[3] ACAD MED SOFIA,FAC PHARM,BU-1000 SOFIA,BULGARIA

[4] UNIV LYON 1,ETUD MAT PLAST & BIOMAT LAB,CNRS,URA 507,F-69622 VILLEURBANNE,FRANCE

来源：

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 1995年 / 10卷 / 04期

关键词：

D O I：

10.1177/088391159501000401

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

A novel method of preparing modified chitosan films was developed. Bi- and tri-component chitosan films were prepared by blending chitosan with high molecular weight polyoxyethylene. The films were loaded with 8-hydroxy-7-iodoquinoline-5-sulfonic acid which was chosen as a model drug. The properties of the films were studied with respect to crystallinity, thermal stability and swelling degree. These properties were shown to depend on the ratio of polyoxyethylene/chitosan. The drug release profile from the films was measured in a buffer at pH 6.8 and 37 degrees C. The antimycotic effect of the films against Candida albicans was determined.

引用

页码：285 / 298

页数：14

共 23 条

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