APOBEC3 cytidine deaminases: Distinct antiviral actions along the retroviral life cycle

被引:31
作者
Chiu, YL
Green, WC
机构
[1] Univ Calif San Francisco, Gladstone Inst Virol & Immunol, San Francisco, CA 94141 USA
[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94141 USA
[3] Univ Calif San Francisco, Dept Microbiol, San Francisco, CA 94141 USA
[4] Univ Calif San Francisco, Dept Immunol, San Francisco, CA 94141 USA
关键词
D O I
10.1074/jbc.R500021200
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The field of human immunodeficiency virus ( HIV) biology has been galvanized by the discovery of innate APOBEC3 cytidine deaminases, which pose powerful barriers to the replication of HIV and other retroviruses. Rapid progress has been made in defining their action, intriguing regulation within cells, expanded range of retroviral targets, and counterstrikes utilized by retroviruses against them. Although scientifically fascinating, advances in APOBEC3 biology may lead to new antiviral drugs and improved lentiviral vectors for gene therapy.
引用
收藏
页码:8309 / 8312
页数:4
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