Stem cells and neuropoiesis in the adult human brain

被引：72

作者：

Steindler, DA

Pincus, DW

机构：

[1] Univ Florida, Coll Med, Program Stem Cell Biol, McKnight Brain Inst,Dept Neurosci, Gainesville, FL 32610 USA

[2] Univ Florida, Coll Med, Program Stem Cell Biol, McKnight Brain Inst,Dept Neurosurg, Gainesville, FL 32610 USA

[3] Univ Florida, Coll Med, Program Stem Cell Biol, Shands Canc Ctr, Gainesville, FL 32610 USA

来源：

LANCET | 2002年 / 359卷 / 9311期

关键词：

D O I：

10.1016/S0140-6736(02)08096-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Stem cells in adult tissues have attracted a great deal of interest. These cells are self-renewing and can give rise to diverse progeny. An extraordinary finding was the presence of stem cells in the mature human brain. This tissue was previously believed incapable of generating new neurons, but neuropoiesis Is now an established phenomenon in the adult brains of mammals, including human beings. This persistent neurogenesis has potential therapeutic applications for various neurological disorders as a source for tissue engraftment and as self-repair by a person's own indigenous population of pluripotent cells or biogenic by-products of their proliferation and differentiation.

引用

页码：1047 / 1054

页数：8

共 85 条

[1] Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas [J].

Aboody, KS ;

Brown, A ;

Rainov, NG ;

Bower, KA ;

Liu, SX ;

Yang, W ;

Small, JE ;

Herrlinger, U ;

Ourednik, V ;

Black, PM ;

Breakefield, XO ;

Snyder, EY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (23) :12846-12851

[2] Transplanted CNS stem cells form functional synapses in vivo [J].

Auerbach, JM ;

Eiden, MV ;

McKay, RDG .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 (05) :1696-1704

[3] Gene therapy of experimental brain tumors using neural progenitor cells [J].

Benedetti, S ;

Pirola, B ;

Pollo, B ;

Magrassi, L ;

Bruzzone, MG ;

Rigamonti, D ;

Galli, R ;

Selleri, S ;

Di Meco, F ;

De Fraja, C ;

Vescovi, A ;

Cattaneo, E ;

Finocchiaro, G .

NATURE MEDICINE, 2000, 6 (04) :447-450

[4] Turning brain into blood: A hematopoietic fate adopted by adult neural stem cells in vivo [J].

Bjornson, CRR ;

Rietze, RL ;

Reynolds, BA ;

Magli, MC ;

Vescovi, AL .

SCIENCE, 1999, 283 (5401) :534-537

[5] Calibration of three-dimensional ultrasound images for image-guided radiation therapy [J].

Bouchet, LG ;

Meeks, SL ;

Goodchild, G ;

Bova, FJ ;

Buatti, JM ;

Friedman, WA .

PHYSICS IN MEDICINE AND BIOLOGY, 2001, 46 (02) :559-577

[6] From marrow to brain: Expression of neuronal phenotypes in adult mice [J].

Brazelton, TR ;

Rossi, FMV ;

Keshet, GI ;

Blau, HM .

SCIENCE, 2000, 290 (5497) :1775-1779

[7] FOCAL BRAIN INJURY AND UP-REGULATION OF A DEVELOPMENTALLY-REGULATED EXTRACELLULAR-MATRIX PROTEIN [J].

BRODKEY, JA ;

LAYWELL, ED ;

OBRIEN, TF ;

FAISSNER, A ;

STEFANSSON, K ;

DORRIES, HU ;

SCHACHNER, M ;

STEINDLER, DA .

JOURNAL OF NEUROSURGERY, 1995, 82 (01) :106-112

[8] Host-guided migration allows targeted introduction of neurons into the embryonic brain [J].

Brustle, O ;

Maskos, U ;

McKay, RDG .

NEURON, 1995, 15 (06) :1275-1285

[9] Embryonic stem cell-derived glial precursors:: A source of myelinating transplants [J].

Brüstle, O ;

Jones, KN ;

Learish, RD ;

Karram, K ;

Choudhary, K ;

Wiestler, OD ;

Duncan, ID ;

McKay, RDG .

SCIENCE, 1999, 285 (5428) :754-756

[10] Generalized potential of adult neural stem cells [J].

Clarke, DL ;

Johansson, CB ;

Wilbertz, J ;

Veress, B ;

Nilsson, E ;

Karlström, H ;

Lendahl, U ;

Frisén, J .

SCIENCE, 2000, 288 (5471) :1660-1663

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