Stem cells and neuropoiesis in the adult human brain

被引：72

作者：

Steindler, DA

Pincus, DW

机构：

[1] Univ Florida, Coll Med, Program Stem Cell Biol, McKnight Brain Inst,Dept Neurosci, Gainesville, FL 32610 USA

[2] Univ Florida, Coll Med, Program Stem Cell Biol, McKnight Brain Inst,Dept Neurosurg, Gainesville, FL 32610 USA

[3] Univ Florida, Coll Med, Program Stem Cell Biol, Shands Canc Ctr, Gainesville, FL 32610 USA

来源：

LANCET | 2002年 / 359卷 / 9311期

关键词：

D O I：

10.1016/S0140-6736(02)08096-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Stem cells in adult tissues have attracted a great deal of interest. These cells are self-renewing and can give rise to diverse progeny. An extraordinary finding was the presence of stem cells in the mature human brain. This tissue was previously believed incapable of generating new neurons, but neuropoiesis Is now an established phenomenon in the adult brains of mammals, including human beings. This persistent neurogenesis has potential therapeutic applications for various neurological disorders as a source for tissue engraftment and as self-repair by a person's own indigenous population of pluripotent cells or biogenic by-products of their proliferation and differentiation.

引用

页码：1047 / 1054

页数：8

共 85 条

[41] Lack of replicative senescence in normal rodent glia [J].

Mathon, NF ;

Malcolm, DS ;

Harrisingh, MC ;

Cheng, LL ;

Lloyd, AC .

SCIENCE, 2001, 291 (5505) :872-875

[42] Emerging neuroprotective strategies for Alzheimer's disease: dietary restriction, telomerase activation, and stem cell therapy [J].

Mattson, MP .

EXPERIMENTAL GERONTOLOGY, 2000, 35 (04) :489-502

[43] Stem cells in the central nervous system [J].

McKay, R .

SCIENCE, 1997, 276 (5309) :66-71

[44] Turning blood into brain:: Cells bearing neuronal antigens generated in vivo from bone marrow [J].

Mezey, É ;

Chandross, KJ ;

Harta, G ;

Maki, RA ;

McKercher, SR .

SCIENCE, 2000, 290 (5497) :1779-1782

[45] NEURAL STEM-CELLS IN THE ADULT MAMMALIAN FOREBRAIN - A RELATIVELY QUIESCENT SUBPOPULATION OF SUBEPENDYMAL CELLS [J].

MORSHEAD, CM ;

REYNOLDS, BA ;

CRAIG, CG ;

MCBURNEY, MW ;

STAINES, WA ;

MORASSUTTI, D ;

WEISS, S ;

VANDERKOOY, D .

NEURON, 1994, 13 (05) :1071-1082

[46] Cell culture - Progenitor cells from human brain after death [J].

Palmer, TD ;

Schwartz, PH ;

Taupin, P ;

Kaspar, B ;

Stein, SA ;

Gage, FH .

NATURE, 2001, 411 (6833) :42-43

[47]

Palmer TD, 2000, J COMP NEUROL, V425, P479, DOI 10.1002/1096-9861(20001002)425:4<479::AID-CNE2>3.0.CO

[48]

2-3

[49]

Papayannopoulou T, 1997, ACTA HAEMATOL-BASEL, V97, P97

[50] Pancreatic stem cells: building blocks for a better surrogate islet to treat type 1 diabetes [J].

Peck, AB ;

Chaudhari, M ;

Cornelius, JG ;

Ramiya, VK .

ANNALS OF MEDICINE, 2001, 33 (03) :186-192

← 1 2 3 4 5 6 7 8 9 →