Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface

被引：88

作者：

Jang, Hyun Soo ^{[1
]}

Park, Kwang No ^{[1
]}

Kim, Jun P. ^{[2
]}

Sim, Sang Jun ^{[2
]}

Kwon, Oh J. ^{[3
]}

Han, Young-Geun ^{[3
]}

Lee, Kyung Shik ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Informat & Commun Engn, Suwon 440746, South Korea

[2] Sungkyunkwan Univ, Dept Chem Engn, Suwon 440746, South Korea

[3] Hanyang Univ, Dept Phys, Seoul 133791, South Korea

来源：

OPTICS EXPRESS | 2009年 / 17卷 / 05期

关键词：

REFRACTIVE-INDEX SENSOR; POLY-L-LYSINE; PLASMON RESONANCE; BRAGG GRATINGS; HYBRIDIZATION;

D O I：

10.1364/OE.17.003855

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is similar to 2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors. (C) 2009 Optical Society of America

引用

页码：3855 / 3860

页数：6

共 20 条

[1] Fabrication and surface characterization of DNA microarrays using amine- and thiol-terminated oligonucleotide probes [J].

Charles, PT ;

Vora, GJ ;

Andreadis, JD ;

Fortney, AJ ;

Meador, CE ;

Dulcey, CS ;

Stenger, DA .

LANGMUIR, 2003, 19 (05) :1586-1591

[2] Real-time detection of DNA interactions with long-period fiber-grating-based biosensor [J].

Chen, Xianfeng ;

Zhang, Lin ;

Zhou, Kaiming ;

Davies, Edward ;

Sugden, Kate ;

Bennion, Ian ;

Hughes, Marcus ;

Hine, Anna .

OPTICS LETTERS, 2007, 32 (17) :2541-2543

[3] Analysis of etched long-period fibre grating and its response to external refractive index [J].

Chiang, KS ;

Liu, YQ ;

Ng, MN ;

Dong, XY .

ELECTRONICS LETTERS, 2000, 36 (11) :966-967

[4] Performance of the Spreeta 2000 integrated surface plasmon resonance affinity sensor [J].

Chinowsky, TM ;

Quinn, JG ;

Bartholomew, DU ;

Kaiser, R ;

Elkind, JL .

SENSORS AND ACTUATORS B-CHEMICAL, 2003, 91 (1-3) :266-274

[5] Detecting hybridization of DNA by highly sensitive evanescent field etched core fiber bragg grating sensors [J].

Chryssis, AN ;

Saini, SS ;

Lee, SM ;

Yi, HM ;

Bentley, WE ;

Dagenais, M .

IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 2005, 11 (04) :864-872

[6] Surface plasmon resonance sensors: review [J].

Homola, J ;

Yee, SS ;

Gauglitz, G .

SENSORS AND ACTUATORS B-CHEMICAL, 1999, 54 (1-2) :3-15

[7] Thinned fiber Bragg gratings as high sensitivity refractive index sensor [J].

Iadicicco, A ;

Cusano, A ;

Cutolo, A ;

Bernini, R ;

Giordano, M .

IEEE PHOTONICS TECHNOLOGY LETTERS, 2004, 16 (04) :1149-1151

[8] Modification of the refractive index response of long period gratings using thin film overlays [J].

Ishaq, IM ;

Quintela, A ;

James, SW ;

Ashwell, GJ ;

Lopez-Higuera, JM ;

Tatam, RP .

SENSORS AND ACTUATORS B-CHEMICAL, 2005, 107 (02) :738-741

[9] Characterization of tunable photonic crystal fiber directional couplers [J].

Jang, Hyun Soo ;

Park, Kwang No ;

Lee, Kyung Shik .

APPLIED OPTICS, 2007, 46 (18) :3688-3693

[10] CHARACTERIZATION OF POLY-L-LYSINE ADSORPTION ONTO ALKANETHIOL-MODIFIED GOLD SURFACES WITH POLARIZATION-MODULATION FOURIER-TRANSFORM INFRARED-SPECTROSCOPY AND SURFACE-PLASMON RESONANCE MEASUREMENTS [J].

JORDAN, CE ;

FREY, BL ;

KORNGUTH, S ;

CORN, RM .

LANGMUIR, 1994, 10 (10) :3642-3648

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