Cellular Fatty Acid Metabolism and Cancer

被引：1642

作者：

Currie, Erin ^{[1
]}

Schulze, Almut ^{[4
]}

Zechner, Rudolf ^{[5
]}

Walther, Tobias C. ^{[6
]}

Farese, Robert V., Jr. ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA

[4] Canc Res UK London Res Inst, Gene Express Anal Lab, London WC2A 3LY, England

[5] Graz Univ, Inst Mol Biosci, A-8010 Graz, Austria

[6] Yale Univ, Dept Cell Biol, New Haven, CT 06520 USA

来源：

CELL METABOLISM | 2013年 / 18卷 / 02期

关键词：

STEAROYL-COA DESATURASE; ATP-CITRATE LYASE; PROLIFERATOR-ACTIVATED-RECEPTOR; ELEMENT-BINDING PROTEINS; PROSTATE-CANCER; GLUTAMINE-METABOLISM; CARBOXYLASE-ALPHA; OVARIAN-CANCER; TUMOR-GROWTH; CELLS;

D O I：

10.1016/j.cmet.2013.05.017

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a common feature of all cancers, requires fatty acids for synthesis of membranes and signaling molecules. Here, we provide a view of cancer cell metabolism from a lipid perspective, and we summarize evidence that limiting fatty acid availability can control cancer cell proliferation.

引用

页码：153 / 161

页数：9

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